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Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara y del OPD Hospitales Civiles de Guadalajara

2005, Número 3

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Inv Salud 2005; 7 (3)


Procesamiento y presentación de antígenos lipídicos por moléculas CD1

Alvarado NA, Hernández UMA

Idioma: Español
Referencias bibliográficas: 43
Paginas: 166-170
Archivo PDF: 254.44 Kb.


RESUMEN

Las moléculas CD1 se clasifican en dos grupos: el grupo 1 incluye las moléculas CD1a, CD1b, CD1c y el grupo 2 CD1d, las cuales interactúan con células T y NKT, respectivamente. A diferencia de las moléculas del MHC, presentan antígenos lipídicos y glucolipídicos de micobacterias. Las moléculas CD1 se localizan en compartimentos intracelulares de las APCs. Existe controversia sobre el procesamiento de los antígenos lipídicos, lo cual influye en la presentación y reconocimiento por células T a través de los TCR. A pesar de los estudios realizados en diferentes modelos experimentales aun se desconocen los mecanismos por los cuales los glucolípidos propios y extraños son diferenciados durante infecciones por micobacterias. La finalidad de esta revisión es mostrar la importancia de la presentación antigénica por moléculas CD1 y su relevancia en la respuesta inmune contra patógenos intracelulares como las micobacterias.


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