Carrillo-Esper R, Peralta-Prado AB, González-Noris P, Ruiz-Hernández AS, Espinoza-García A

Idioma: Ingles.
Referencias bibliográficas: 3
Paginas: 145-146
Archivo PDF: 150.27 Kb.

FRAGMENTO

LEUKOERYTHROBLASTIC REACTION

A 51-year-old patient without previous medical history was admitted to the hospital with a clinical picture of respiratory distress. During evaluation, presence of bilateral reticulonodular pulmonary infiltrates, right pleural effusion and left ovarian mass with ascitic fluid was documented.
Laboratories showed CA125: 768 U/mL, CA19-9: 1,880 U/mL, CA16-3: 477 nU/L, carcinoembryonic antigen level 1,010 ng/mL and alpha-fetoprotein 1.7 ng/mL. Cell blood count: hemoglobin 10.2 g/dL, leukocytes 15,700 cells/µL, platelets 72,000 cells/µL, normal ranged reticulocytes and negative Coombs. The peripheral blood smear (PBS) examination revealed erythroblasts (4/100 leukocytes), myelocytes, metamyelocytes, keratocytes, ovalocytes, anisocytosis and mycrocitosis, which are characteristic of a leukoerythroblastic reaction (Figure 1).

REFERENCIAS (EN ESTE ARTÍCULO)

1. Shamdas GJ, Ahmaim FR, Matzner MB, Rifchie JM. Leukoerythroblastic anemia in metastatic prostate cancer. Cancer 1993; 71: 3594-600.

2. Delsol G, Guiu-Godfrin B, Guiu M, Pris J, Corberand J, Fabre J. Leukoerythroblastosis and cancer frequency, prognosis and physiopathologic significance. Cancer 1979; 44: 1009-13.

3. George JN. Systemic malignancies as a cause of unexpected microangiopathic hemolytic anemia and thrombocytopenia. Oncology (Williston Park) 2011; 25(10): 908-14.