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2018, Número 3

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Salud Mental 2018; 41 (3)


Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders

Morales-Marín ME, Aguilar M, Albores L, Ballesteros A, Castro X, Chicalote C, Gómez A, Gutiérrez N, Lanzagorta N, López F, Márquez C, Morales N, Náfate O, Sánchez P, Balboa AM, Nicolini H

Idioma: Ingles.
Referencias bibliográficas: 26
Paginas: 117-121
Archivo PDF: 331.17 Kb.


RESUMEN

Introducción. El estudio de los trastornos del espectro autista a nivel genético es de suma importancia para entender su origen. En México existen pocos trabajos abordados desde esta perspectiva. Objetivo. Investigamos el papel de la variante del gen rs6265 G/A del factor neurotrófico derivado del cerebro (BDNF) para el análisis del polimorfismo de un solo nucleótido en niños mexicanos con TEA por medio de un diseño de asociación de casos y controles. Método. Realizamos un estudio piloto mediante un análisis de casos y controles ajustando por género, edad y ancestría. Resultados. Nuestro estudio no encontró asociación entre el polimorfismo del gen BDNF rs6265 y TEA [p = .419, OR = 1.597 (.514, 4.967)]. Discusión y conclusión. A nivel mundial, los resultados de estudios de asociación caso-control con el rs6265 de BDNF son controvertidos y no siempre se replican. Esto puede deberse a la etnicidad de nuestra población y a otros factores no estudiados en el presente trabajo. El estudio sugiere que el SNP rs6265 no contribuye a la susceptibilidad al TEA en población mexicana.


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