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>Revistas >Gaceta Médica de México >Año 2018, No. 3


Serna-Higuita LM, Nieto-Ríos JF, Ocampo-Kohn C, Aristizabal-Alzate A, Zuluaga-Valencia GA, Jaimes-Barragán F
Lipocalina asociada con gelatinasa del neutrófilo como predictor de disfunción del injerto a un año del trasplante renal
Gac Med Mex 2018; 154 (3)

Idioma: Español
Referencias bibliográficas: 38
Paginas: 275-282
Archivo PDF: 295.05 Kb.


Texto completo




RESUMEN

Introducción: Estudios recientes sugieren que la lipocalina asociada con la gelatinasa del neutrófilo urinaria (NGALu) es superior a la creatinina para la detección temprana de la disfunción del injerto renal, pero son pocos los estudios que evalúan su utilidad como predictor a largo plazo de dicha función. Objetivo: Explorar si los valores de NGALu en las primeras 48 horas después del trasplante renal predicen la función del injerto a largo plazo. Método: Cohorte prospectiva en la que se evaluaron los valores de NGALu a las 2, 12, 24 y 48 horas postrasplante renal. Resultados: Se valoraron 79 pacientes trasplantados renales. Al año de seguimiento, 30.4 de los pacientes presentó disfunción del injerto. No se encontraron diferencias estadísticamente significativas entre los valores de NGALu y la función a un año del injerto renal (p = 0.65); el análisis multivariado mostró que ningún valor de NGALu fue un marcador predictor de disfunción del injerto a un año del trasplante renal. Conclusión: Los valores de NGALu obtenidos en las primeras 48 horas postrasplante no se asociaron con disfunción del injerto a un año del trasplante renal.


Palabras clave: Lipocalina, Pérdida del injerto, Trasplante renal.


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>Revistas >Gaceta Médica de México >Año2018, No. 3
 

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