Entrar/Registro  
INICIO ENGLISH
 
Revista Médica MD
   
MENÚ

Contenido por año, Vol. y Num.

Índice de este artículo

Información General

Instrucciones para Autores

Mensajes al Editor

Directorio






>Revistas >Revista Médica MD >Año 2018, No. 2


Lazcano-Becerra M, Velarde-Ruiz VJA, Aldana-Ledesma JM, Gómez-Castaños PC, Díaz-Aceves PE, García-Jiménez ES
Evolución de los fármacos antisecretores: Farmacología y usos clínicos
Rev Med MD 2018; 9.10 (2)

Idioma: Español
Referencias bibliográficas: 62
Paginas: 174-184
Archivo PDF: 668.97 Kb.


Texto completo




RESUMEN

Los fármacos antisecretores han sido una necesidad médica histórica, contando con los primeros fármacos antisecretores (antimuscarínicos) en los 50s, sin embargo, fue en la década de los 70s, cuando se lanzó al mercado el primer antagonista del receptor de la histamina, la cimetidina, lo que marcó un parteaguas en el manejo de la enfermedad ácido péptica. Posteriormente surgió la ranitidina en los 80s, llegando a ser uno de los fármacos mejor vendidos en 1988.
Los inhibidores de bomba de protones han llegado a ser actualmente los fármacos más prescritos, incluso se pueden adquirir sin prescripción médica, lo que los ha puesto en los primeros lugares de medicamentos consumidos a nivel mundial. El omeprazol fue el primer inhibidor de la bomba de protones en el mercado en 1989, seguido del lansoprazol, rabeprazol, pantoprazol, esomeprazol y dexlansoprazol. Tal efectividad en la secreción ácida ha ocasionado efectos adversos asociados, como osteoporosis, alteraciones en la absorción de hierro, vitamina B12, hipomagnesemia, daño renal agudo y crónico, demencia, infarto agudo al miocardio, infección por Clostridium difficile, entre otros; a pesar de esto, la mayoría con poca evidencia y sólo reportado en estudios observacionales.
Estos medicamentos utilizarse en personas con indicación médica precisa y se debe de prescribir la menor dosis efectiva por el menor tiempo posible, para limitar la exposición indebida y limitar sus efectos adversos. Esta revisión se enfoca en los acontecimientos históricos, usos clínicos, efectos adversos y trascendencia del uso de los antisecretores, así como las proyecciones de su uso a futuro.


Palabras clave: Antiácidos, dispepsia, ERGE, H. pylori, inhibidores de bomba de protones.


REFERENCIAS

  1. Vaezi MF, Yang YX, Howden CW. Complications of proton pump inhibitor therapy. Gastroenterology. 2017 Jul; 153(1):35-48.

  2. Heidelbaugh JJ, Kim AH, Chang R, Walker PC. Overutilization of proton-pump inhibitors: what the clinician needs to know. Ther Adv Gastroenterol. 2012 Jul;5(4):219–32

  3. Sakurai K, Suda H. Efficacy of acid suppression therapy. In: Tominaga K, Kusunoki H (eds) Functional dyspepsia: Evidences in pathophysiology and treatment. Singapore: Springer; 2018.

  4. Oshima T, Miwa H. Potent potassium-competitive acid blockers: A new era for the treatment of acidrelated diseases. J Neurogastroenterol Motil. 2018 Jul 30;24(3):334-44.

  5. Esquivel-Ayanegui F. Nuevos fármacos en el tratamiento de la ERGE. Rev Gastroenterol Mex. 2011 11.Strand DS, Kim D, Peura DA. 25 years of proton pump inhibitors: A comprehensive review. Gut Liver. 2017 Jan 15;11(1):27-37.

  6. Schubert ML, Peura DA. Control of gastric acid secretion in health and disease. Gastroenterology. 2008 Jun;134(7):1842-60.

  7. Silverthorn D. Fisiología Humana, Un enfoque integrado. 4º ed. Buenos Aires, Argentina: Editorial Médica Panamericana; 2008.

  8. Andrés E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni M, Perrin AE, Noblet-Dick, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004 Aug 3;171(3):251-9.

  9. Rodríguez-Palomo D, Alfaro-Benavides A. Actualización de la fisiología gástrica. Med Leg Costa Rica. 2010 Sep;27(2):59-68.

  10. 10.Yakabi K, Kawashima J, Kato S. Ghrelin and gastric acid secretion. World J Gastroenterol. 2008 Nov 7; 14(41) 6334-8.

  11. 11.Strand DS, Kim D, Peura DA. 25 years of proton pump inhibitors: A comprehensive review. Gut Liver. 2017 Jan 15;11(1):27-37.

  12. 12.Baron JH. The history of acid inhibition. Yale J Biol Med. 1994 May-Aug;67(3-4):97-106

  13. 13.Rosenfeld L. William Prout: early 19 century physician-chemist. Clin Chem. 2003 Apr;49(4):699- 705.

  14. 14.Fiske SC. Peptic ulcer disease, cytoprotection, and prostaglandins. Arch Intern Med. 1988 Oct;148(10):2112-3.

  15. 15.Molinder HK. The development of cimetidine: 1964-1976. A human story. 1994 Oct;19(3):248-54

  16. 16.Kounenis G, Koutsoviti-Papadopoulou M, Elezoglou A, Voutsas A. Comparative study of the H2-receptor antagonists cimetidine, ranitidine, famotidine and nizatidine on the rabbit stomach fundus and sigmoid colon. J Pharmacobiodyn. 1992 Oct;15(10):561-5.

  17. 17.Senn-Bilfinger J, Sturm E. The development of a new proton-pump inhibitor: the case history of pantoprazole. In: Fischer J, Ganellin R (eds) Analogue-based drug discovery. Wiley; 2006.

  18. 18.Savarino V, Dulbecco P, de Bortoli N, Ottonello A, Savarino E. The appropriate use of proton pump inhibitors (PPIs): Need for a reappraisal. Eur J Intern Med. 2017 Jan;37:19-24.

  19. 19.Yu LY, Sun LN, Zhang XH, Li YQ, Yu L, Yuan ZQ, et al. A Review of the novel application and potential adverse effects of proton pump inhibitors. Adv Ther. 2017 May;34(5):1070-86.

  20. 20.Ito T, Jensen RT. Association of long-term proton pump inhibitor therapy with bone fractures and effects on absorption of calcium, vitamin B12, iron and magnesium. Curr Gastroenterol Rep. 2010 Dec;12(6):448–57.

  21. 21.Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013 Dec 11;310(22):2435-42. 22.Mackay JD, Bladon PT. Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series. QJM. 2010 Jun;103(6):387-95.

  22. Cundy T, Dissanayake A. Severe hypomagnesaemia in long-term users of protonpump inhibitors. Clin Endocrinol (Oxf). 2008 Aug;69(2)338-41.

  23. 24.Sampathkumar K, Ramalingam R, Prabakar A, Abraham A. Acute interstitial nephritis due to proton pump inhibitors. Indian J Nephrol. 2013 Jul;23(4):304-7.

  24. 25.Yang Y, George KC, Shang WF, Zeng R, Ge SW, Xu G. Proton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies. Drug Des Devel Ther. 2017 Apr 24;11:1291-9.

  25. 26.Ogawa R, Echizen H. Drug-drug interaction profil esofprotonp umpinhi bitors. Clin Pharmacokinet. 2010 Aug;49(8):509-33.

  26. 27.Sierra F, Suarez M, Rey M, Vela MF. Systematic review: proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmacol Ther. 2007 Aug;26(4):545-53.

  27. 28.Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006 Nov;5(11):949- 60.

  28. 29.Montull B, Menéndez R, Torres A, Reyes S, Méndez R, Zalacaín R, et al. Predictors of severe sepsis among patients hospitalized for communityacquired pneumonia. PLoS One. 2016 Jan 4;11(1):1- 9.

  29. 30.Gomm W, von Holt K, Thomé F, Broich K, Maier W, Fink A, et al. Association of proton pump in hibitors with riskof dementia: A pharmacoepidemioloical claims data analysis. JAMA Neurol. 2016 Apr;73(4):410-6.

  30. 31.Taipale H, Tolppanen AM, Tiihonen M, Tanskanen A, Tiihonen J, Hartikainen S. No Association between proton pump inhibitor use and risk of Alzheimer's disease. Am J Gastroenterol. 2017 Dec;112(12):1802-08.

  31. 32.Ghebremariam YT, LePendu P, Lee JC, Erlanson DA, Slaviero A, Shah NH, et al. An unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factora symmetricdime thy largine. Circulation. 2013 Aug 20;128(8):845-53.

  32. 33.Jump RLP, Pultz MJ, Donskey CJ. Vegetative Clostridium difficile survives in room air on moist surfaces and in gastric contents with reduced acidity: a potential mechanism to explain the association between proton pump inhibitors and C. difficile-associated diarrhea?. Antimicrob Agents Chemother. 2007 Aug;51(8):2883-7.

  33. 34.Arriola V, Tischendorf J, Musuuza J, Barker A, Rozelle JW, Safdar N. Assessing the risk of hospitalacquired Clostridium difficile infection with proton pump inhibitor use: a meta-analysis. Infect Control Hosp Epidemiol. 2016 Dec;37(12):1408-17.

  34. 35.Su T, Lai S, Lee A, He X, Chen S. Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth. J Gastroenterol. 2018 Jan;53(1):27-36.

  35. 36.Bonderup OK, Nielsen GL, Dall M, Pottegard A, Hallas J. Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. Aliment Pharmacol Ther. 2018 Sep;48(6):618-25.

  36. 37.Dam G, Vilstrup H, Watson H, Jepsen P. Proton pump inhibitors as a risk factor for hepatic encefalopathy and spontaneous bacterial peritonitis in cirrhosis patients with ascites. Hepatology. 2016 Oct;64(4):1265-72.

  37. 38.Eom CS, Jeon CY, Lim JW, Cho EG, Park SM, Lee KS. Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis. CMAJ. 2011 Feb;183(3):310-9.

  38. 39.Clark DW, Strandell J. Myopathy including polymyositis: a likely class adverse effect of proton pump inhibitors? Eur J Clin Pharmacol. 2006 Jun;62(6)473-9.

  39. 40.Jalving M, Koornstra JJ, Wesseling J, Boezen HM, de Jong S, Kleibeuker JH. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther. 2006 Nov 1;24(9):1341-8.

  40. 41.Malfertheiner P, Kandulski A, Venerito M. Protonpump inhibitors: understanding the complications and risks. Nat Rev Gastroenterol Hepatol. 2017 Dec; 14(12):697-710.

  41. 42.Wedemeyer R, Blume H. Pharmacokinetic drug interaction profiles of proton pump inhibitors: an update. Drug Saf. 2014 Apr;37(4):201-11.

  42. 43.Shin JM, Sachs G. Pharmacology of proton pump in hibitors. Curr Gastroenterol Rep. 2010 Dec;10(6):528-34

  43. 44.Scarpignato C, Pelosini I, Di Mario F. Acid suppression therapy: where do we go from here? Dig Dis. 2006;24(1-2):11-46.

  44. 45.Shin JS, Lee JY, Cho KH, Park HL, Kukulka M, Wu J T, et al. The pharmacokinetics, pharmacodynamics and safety of oral doses of ilaprazole 10, 20 and 40 mg and esomeprazole 40 mg in healthy subjects: a randomised, open-label crossover study. Aliment Pharmacol Ther. 2014 Sep;40(5):548-61.

  45. 46.Wang H, Lang L, Ou N, Shi R, Hu H, Hu P, et al. Pharmacokinetics, pharmacodynamics and safety of multiple-infusion ilaprazole in healthy chinese subjects. Clin Drug Investig. 2016 Jun;36(6):463-70.

  46. 47.Ji XQ, Du JF, Chen G, Chen G, Yu B. Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis. World J Gastroenterol. 2014 May 7;20(17):5119-23

  47. 48.Song IJ, Kim HK, Lee NK, Lee SK. Prospective single arm study on the effect of ilaprazole in patients with heartburn but no reflux esophagitis. Yonsei Med J. 2018 Oct;59(8):951-9.

  48. 49.Ahn HJ, Kim DP, Chu MS, Yun HJ, Kim SH, Lee SW, et al. Efficacy and safety of the triple therapy containing ilaprazole, levofloxacin, and amoxicillin as first-line treatment in Helicobacter pylori infections. Gastroenterol Res Pract. 2017;2017:1654907.

  49. 50.Bang CS, Shin WG, Seo SI, Choi MH, Jang HJ, Park SW, et al. Effect of ilaprazole on the healing of endoscopic submucosal dissection-induced gastric ulcer: randomized-controlled, multicenter study. Surg Endosc. 2018.

  50. 51.Xue Y, Qin X, Zhou L, Lin S, Wang L, Hu H, et al. A randomized, double-blind, active-controlled, multi-center study of ilaprazole in the treatment of reflux esophagitis. Clin Drug Investig. 2016 Dec;36(12):985-92.

  51. 52.Sakurai Y, Nishimura A, Kennedy G, Hibberd M, Jenkins R, Okamoto H, et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of single rising TAK-438 (Vonoprazan) doses in healthy male Japanese/non-Japanese subjects. Clin Transl Gastroenterol. 2015 Jun 25;6:e94.

  52. 53.Jenkins H, Sakurai Y, Nishimura A, Okamoto H, Hibberd M, Jenkins R, et al. Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2015 Apr;41(7):636-48.

  53. 54.Jung YS, Kim EH, Park CH. Systematic review with meta-analysis: the efficacy of vonoprazanbased triple therapy on Helicobacter pylori eradication. Aliment Phar macol Ther. 2017 Jul;46(2):106-14.

  54. 55.Li M, Oshima T, Horikawa T, Tozawa K, Tomita T, Fukui H, etl al. Systematic review with metaanalysis: Vonoprazan, a potent acid blocker, is superior to proton-pump inhibitors for eradication of clarithromycin-resistant strains of Helicobacter pylori. Helicobacter. 2018 Aug;23(4):e12495.

  55. 56.Ashida K, Sakurai Y, Nishimura A, Kudou K, Hiramatsu N, Umegaki E, et al. Randomised clinical trial: a dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis. Aliment Pharmacol Ther. 2015 Sep;42(6):685-95.

  56. 57.Ashida K, Iwakiri K, Hiramatsu N, Sakurai Y, Hori T, Kudou K, et al. Maintenance for healed erosive esophagitis: Phase III comparison of vonoprazan with lansoprazole. World J Gastroenterol. 2018 Apr14;24(14):1550-61.

  57. 58.Miwa H, Uedo N, Watari J, Mori Y, Sakurai Y, Takanami Y, et al. Randomised clinical trial: efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers - results from two phase 3, non-inferiority randomised controlled trials. Aliment Pharmacol Ther. 2017 Jan;45(2):240-52.

  58. 59.Mizokami Y, Oda K, Funao N, Nishimura A, Soen S, Kawai T, et al. Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled noninferiority and single-blind extension study. Gut. 2018 Jun;67(6):1042-51.

  59. 60.Kawai T, Oda K, Funao N, Nishimura A, Matsumoto Y, Mizokami Y, et al. Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study. Gut. 2018 Jun;67(6):1033-41.

  60. 61.Oshima T, Wu L, Li M, Fukui H, Watari J, Miwa H. Magnitude and direction of the association between Clostridium difficile infection and proton pump inhibitors in adults and pediatric patients: a systematic review and meta-analysis. J Gastroenterol. 2018 Jan;53(1):84-94.

  61. 62.Takahashi N, Take Y. Tegoprazan, a novel potassium-competitive acid blocker to control gastric acid secretion and motility. J Pharmacol Exp Ther. 2018 Feb;364(2):275-86.



>Revistas >Revista Médica MD >Año2018, No. 2
 

· Indice de Publicaciones 
· ligas de Interes 






       
Derechos Resevados 2019