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Revista de Divulgación del INSTITUTO DE MEDICINA FORENSE de la UNIVERSIDAD VERACRUZANA

2016, Número 1

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Rev Mex Med Forense 2016; 1 (1)


Detección de 3,4- metilenodioximetanfetamina (MDMA) en saliva

Denis-Rodríguez E, Hermida-Moreno A

Idioma: Español
Referencias bibliográficas: 30
Paginas: 53-59
Archivo PDF: 375.28 Kb.


RESUMEN

Las anfetaminas son drogas de abuso frecuentemente usadas en la actualidad; la 3,4-metilenodioximetanfetamina (MDMA), coloquialmente llamada “éxtasis”, es usada por millones de personas en el mundo; los métodos de detección rápida se han realizado habitualmente en muestras de sangre y orina; el uso de la saliva como sustrato biológico ofrece ventajas sobre los demás sustratos en cuanto a la facilidad de obtención y la dificultad para adulterar las muestras. En esta revisión analizamos las evidencias existentes acerca de las técnicas metodológicas usadas en la detección salival de MDMA y la amplitud de su campo de aplicación.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Armenta S, Garriques S, de la Guardia M (2015). Analysis of ecstasy in oral fluid by ion mobility spectrometry and infrared spectroscopy after liquid-liquid extraction. J Chromatogr A, 1384, 1-8.

  2. Anizan S, Huestis, MA (2014). The potential role of oral fluid in antidoping testing. Clin Chem, 60(2): 307-22.

  3. Aps JK, Martens LC (2005) Review: the physiology of saliva and transfer of drugs into saliva. Forensic Sci Int ,150:119–31

  4. Barnes AJ, Scheidweiler KB, Kolbrich-Spargo EA, Gorelick DA, Goodwin RS, Huestis MA. MDMA and metabolite disposition in expectorated oral fluid after controlled oral MDMA administration. Ther Drug Monit 2011; 33:602–8

  5. Castaneto MS, Barnes AJ (2013). Identifying metamphetamine exposure in children. Ther Drug Monit, 35(6): 823-30.

  6. Drummer OH (2006). Drug testing in oral fluid. Clinical and Biochemical Reviews. 27:147–59

  7. Drummer OH (2008). Introduction and review of collection techniques and applications of drug testing of oral fluid. Therapeutic Drug Monitoring; 30:203–206.

  8. Desrosiers NA, Barnes AJ, Hartman RL (2013). Oral fluid and plasma 3,4-methylenedioxymethamphetamine (MDMA) and metabolite correlation after controlled oral MDMA administration. Anal Bioanal Chem, 405(12): 4067-76.

  9. Davey J, Armstrong K, Martin P (2014). Results of the Queensland 2007-2012 roadside drug testing program: The prevalence of three illicit drugs. Accid Anal Prev, 65: 11-17.

  10. Farre M, de la Torre R, Mathuna BO (2004). Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics. Psychopharmacology; 173:364–75.

  11. Green AR, Mechan AO, Elliott JM (2003). The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) Pharmacol Rev. 55:463–508

  12. Kraemer T, Maurer HH (2002). Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives. Therapeutic Drug Monitoring; 24:277–289

  13. Kolbrich EA, Goodwin RS, Gorelick DA (2008). Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults. Therapeutic drug monitoring; 30:320–32

  14. Langel K, Engblom C, Pehrsson A (2008). Drug testing in oral fluid-evaluation of sample collection devices. J Anal Toxicol 2008; 32:393–401.

  15. Langel K, Gierde H, Favretto D (2014). Comparison of drug concentrations between whole blood and oral fluid. Drug Test Anal, 6(5): 461-71.

  16. Liu HC, Lee HT, Hsu YC (2015). Direct Injection LC-MS-MS Analysis of Opiates, Methamphetamine, Buprenorphine, Methadone and Their Metabolites in Oral Fluid from Substitution Therapy Patients. J Anal Toxicol, epub ahead of print.

  17. Lund HM, Oiestad EL, Gjerde H (2011). Drugs of abuse in oral fluid collected by two different sample kits: stability testing and validation using ultra performance tandem mass spectrometry analysis. J Chromatogr B Analyt Technol Biomed Life Sci; 879:3367–77

  18. Montesano C, Simeoni MC, Curini R (2015). Determination of illicit drugs and metabolites in oral fluid by microextraction on packed sorbent coupled with LC-MS/MS. Anal Bioanal Chem, 407(13): 3647-58.

  19. Navarro M, Pichini S, Farre Ml (2001). Usefulness of saliva for measurement of 3,4-methylenedioxymethamphetamine and its metabolites: correlation with plasma drug concentrations and effect of salivary pH. Clinical Chemistry; 47:1788–1795.

  20. Nieddu M, Burrai L, Trignano C (2014). Evaluation of commercial multi- drug oral fluid devices to identify 39 new amphetamine-designer drugs. Leg Med, 16(2): 106-9.

  21. Peters FT, Samyn N, Kraemer T (2007). Negative-ion chemical ionization gas chromatography-mass spectrometry assay for enantioselective measurement of amphetamines in oral fluid: application to a controlled study with MDMA and driving under the influence cases. Clin Chem, 53(4):702-10.

  22. Samyn N, De Boeck G, Wood M (2002). Plasma, oral fluid and sweat wipe ecstasy concentrations in controlled and real life conditions. Forensic Science International; 128:90–97.

  23. Samyn N, Laloup M, De Boeck G (2007). Bioanalytical procedures for determination of drugs of abuse in oral fluid. Anal Bioanal Chem; 388:1437–53

  24. Scheidweiler KB, Huestis MA (2006). A validated gas chromatographic-electron impact ionization mass spectrometric method for MDMA, methamphetamine and metabolites in oral fluid. Journal of Chromatography B835:90–99.

  25. Schepers RJ, Oyler JM, Joseph RE Jr (2003). Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers. Clin Chem; 49:121–32.

  26. Sergi M, Bafile E, Compagnone D (2009). Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MM. Anal Bioanal Chem, 393(2): 709-18.

  27. Vearrier D, Curtis JA, Greenberg MI (2010). Biological testing for drugs of abuse. EXS; 100:489–517.

  28. Wilson L, Jehanli A, Hand C (2007). Evaluation of a rapid oral fluid point-of-care test for MDMA. J Anal Toxicol, 31(2): 98-104.

  29. Wood M, Laloup M, Fernandez M (2005). Quantitative analysis of multiple illicit drugs in preserved oral fluid by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Forensic Science International; 150:227–38.

  30. Wong RC, Tran M, Tung JK. (2005). Oral fluid drug tests: effects of adulterants and foodstuffs. Forensic Sci Int; 150:175–80.




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