Rito-Domingo M, Cruz-García K, Escartín-Pérez RE, Mancilla-Díaz JM, López-Alonso VE

Idioma: Español
Referencias bibliográficas: 24
Paginas: 1-10
Archivo PDF: 650.06 Kb.

RESUMEN

El objetivo de la presente investigación fue evaluar el efecto de la estimulación delos receptores CRH2 del núcleo paraventricular hipotalámico sobre la ingesta de alimento y laexpresión de la secuencia de saciedad conductual (SSC) en ratas adrenalectomizadas. Se tra-bajó con ocho grupos independientes de ratas Wistar, cuatro grupos adrenalectomizados (ADX)y cuatro con falsa cirugía. A todos los sujetos se les implantó una cánula en el núcleo paraven-tricular hipotalámico, y se les administró uno de cuatro tratamientos: vehículo, urocortina 2(UCN2, agonista de CRH2), antisauvagina 30 (antagonista de CRH2), y antisauvagina-30 + UCN2(pretratamiento). La administración de UCN2 redujo la ingesta de hidratos de carbono y degrasas en las ratas ADX, debido a la interrupción de la SSC; mientras que en las ratas con falsacirugía, la UCN2 solo disminuyó la ingesta de grasas, debido al adelanto de la SSC. El pretra-tamiento previno los efectos inducidos en las ratas ADX, pero no en las ratas con falsa cirugía.Estos resultados indican que los receptores CRH2 modularon la ingesta y la SSC en las ratas ADX,lo que constituye un aporte importante en la comprensión de la etiología de la anorexia y delpatrón conductual asociado a esta.

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