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2006, Número 2

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Rev Inst Nal Enf Resp Mex 2006; 19 (2)


Alteración de la actividad inflamatoria regulada por TH1-TH2 en asma

Martínez-Ramírez I, Avilés-Salas A, Nava-Reyes H, Ramos-Godínez MP, Carvajal-Sandoval G, Zamudio-Cortés P, Parra-Hernández E

Idioma: Español
Referencias bibliográficas: 40
Paginas: 136-142
Archivo PDF: 150.88 Kb.


RESUMEN

El asma afecta entre 100 y 150 millones de personas en el mundo. En la actualidad, esta enfermedad se puede controlar por diversas terapias, pero no se puede curar y representa una de las enfermedades más costosas y frecuentes en los sistemas de salud en muchos países, por lo que son necesarias estrategias de prevención eficientes para reducir la morbimortalidad y costos económicos; esto requiere, entre otros, de un conocimiento detallado de los mecanismos inmunológicos y fisiológicos involucrados en el asma. Esta revisión sintetiza el conocimiento sobre la inflamación mediada por TH2 en asma y se discute el origen de las células CD4+ TH2 y el papel de las citocinas TH2 en la producción y mantenimiento de la inflamación de las vías respiratorias en esta enfermedad.


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