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2020, Número 1

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Rev Educ Bioquimica 2020; 39 (1)


Topología Genómica, Transcripción y Replicación, tres procesos funcionalmente entrelazados

Jácome-López K, Furlan-Magaril M

Idioma: Español
Referencias bibliográficas: 59
Paginas: 14-25
Archivo PDF: 299.60 Kb.


RESUMEN

Con la finalidad de entender cómo se relaciona la topología del genoma con la transcripción, en esta revisión analizaremos las evidencias que sugieren a la organización tridimensional del genoma como regulador de la transcripción y datos que sugieren a la transcripción como el proceso regulador de la organización del genoma. Por otro lado, resulta interesante entender cómo la maquinaria de replicación del DNA se enfrenta a esta organización tridimensional, por lo que abordaremos también evidencias recientes de cómo la estructura tridimensional del genoma puede ser relevante durante el proceso de replicación y las implicaciones de este proceso en la topología genómica.


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