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Instituto Nacional de Salud Pública

2020, Número 4

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salud publica mex 2020; 62 (4)


Variación molecular de la dehidrofolato reductasa de Plasmodium vivax en México y Nicaragua contrasta con la que ocurre en Sudamérica

González-Cerón L, Rodríguez MH, Montoya A, Santillán-Valenzuela F, Corzo-Gómez JC

Idioma: Ingles.
Referencias bibliográficas: 59
Paginas: 364-371
Archivo PDF: 275.32 Kb.


RESUMEN

Objetivo. Determinar mutaciones en la dihydrofolato reductasa de P. vivax (Pvdhfr) en parásitos de México y Nicaragua, y comparar con lo reportado en América. Material y métodos. Del ADN de sangres infectadas con P. vivax de pacientes, el gen pvdhfr se amplifico y secuenció, y se contrastócon lo observado en América. Resultados. No se detectaron mutaciones asociadas con la resistencia debida a pirimetamina. Los parásitos de Nicaragua tuvieron una mutación sinónima y variación en la región repetida. Se reportaron frecuentes mutaciones asociadas con la resistencia a la pirimetamina en Sudamérica. Conclusiones. La ausencia de polimorfismos en Pvdhfr sugiere que no se han seleccionado ni introducido parásitos resistentes en la zona de estudio, lo que resulta muy útil para la vigilancia epidemiológica.


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