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Revista Médica Sinergia

2020, Número 09

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Revista Médica Sinergia 2020; 5 (09)


Colchicina como tratamiento del síndrome de fiebre periódica, estomatitis aftosa, faringitis y adenitis cervical pediátrico (PFAPA): un estudio de caso

González HK, Varela MAC, Barrantes AGJ

Idioma: Español
Referencias bibliográficas: 33
Paginas: 1-9
Archivo PDF: 173.17 Kb.


RESUMEN

El síndrome fiebre periódica, estomatitis aftosa, faringitis y adenitis cervical (PFAPA) es un tipo frecuente de fiebre recurrente en infantes. Entre las opciones de tratamiento se encuentran: antiinflamatorios no esteroideos, cimetidina, esteroides, colchicina y la amigdalectomía. La colchicina funciona como un modulador del sistema inmunológico, sin producir inmunosupresión, y es el tratamiento profiláctico de elección en el PFAPA, disminuyendo la duración e intensidad de las crisis febriles y aumentando el intervalo entre episodios.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Ali N, Sartori-Valinotti J, Bruce A. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. Clinics in Dermatology. 2016; 34(4): 482-486. https://doi.org/10.1016/j.clindermatol.2016.02.021

  2. Vanoni F, Theodoropoulou K, Hofer M. PFAPA syndrome: a review on treatment and outcome. Pediatric Rheumatology. 2016; 14(1). https://doi.org/10.1186/s12969-016-0101-9

  3. Theodoropoulou K, Vanoni F, Hofer M. Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis. Current Rheumatology Reports. 2016; 18(4). https://doi.org/10.1007/s11926-016-0567-y

  4. Wekell P. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis síndrome - PFAPA syndrome. La Presse Médicale. 2019; 48(1): 77-87. https://doi.org/10.1016/j.lpm.2018.08.016

  5. Batu E. Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: main features and an algorithm for clinical practice. Rheumatology International. 2019; 39(6): 957-970. https://doi.org/10.1007/s00296-019-04257-0

  6. Tejesvi M, Uhari M, Tapiainen T, Pirttilä A, Suokas M, Lantto U et al. Tonsillar microbiota in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome. European Journal of Clinical Microbiology & Infectious Diseases. 2016; 35(6): 963-970. https://doi.org/10.1007/s10096-016- 2623-y

  7. Kraszewska-Głomba B, Matkowska-Kocjan A, Szenborn L. The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research. Mediators of Inflammation. 2015. https://doi.org/10.1155/2015/563876

  8. Kettunen S, Lantto U, Koivunen P, Tapiainen T, Uhari M, Renko M. Risk factors for periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: a case-control study. European Journal of Pediatrics. 2018; 177(8): 1201-1206. https://doi.org/10.1007/s00431-018-3175-1

  9. Nalbantoğlu A, Nalbantoğlu B. Vitamin D deficiency as a risk factor for PFAPA syndrome. International Journal of Pediatric Otorhinolaryngology. 2019; 121: 55-57. https://doi.org/10.1016/j.ijporl.2019.02.047

  10. Perko D, Debeljak M, Toplak N, Avčin T. Clinical Features and Genetic Background of the Periodic Fever Syndrome with Aphthous Stomatitis, Pharyngitis, and Adenitis: A Single Center Longitudinal Study of 81 Patients. Mediators of Inflammation. 2015. https://doi.org/10.1155/2015/293417

  11. Gaggiano C, Rigante D, Sota J, Grosso S, Cantarini L. Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review. Clinical Rheumatology. 2018; 38(1): 11-17. https://doi.org/10.1007/s10067-018-4361-2

  12. Więsik-Szewczyk E, Wolska-Kuśnierz B, Jahnz-Różyk K. Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome persisting to adulthood - an example of a diagnostic and therapeutic challenge. Reumatologia/Rheumatology. 2019; 57(5): 292-296. https://doi.org/10.5114/reum.2019.89523

  13. Angelidis C, Kotsialou Z, Kossyvakis C, Vrettou A, Zacharoulis A, Kolokathis F et al. Colchicine Pharmacokinetics and Mechanism of Action. Curr Pharm Des. 2018; 24(6): 659-663. https://doi.org/10.2174/1381612824666180123110042

  14. Dasgeb B, Kornreich D, McGuinn K, Okon L, Brownell I, Sackett D. Colchicine: an ancient drug with novel applications. British Journal of Dermatology. 2018; 178: 350-356. https://doi.org/10.1111/bjd.15896

  15. Katz J, Langevitz P, Shemer J, Barak S, Livneh A. Prevention of recurrent aphthous stomatitis with colchicine: An open trial. J Am Acad Dermatol. 1994; 31: 459-461. https://doi.org/10.1016/S0190- 9622(94)70211-X

  16. Butbul-Aviel Y, Tatour S, Gershoni Baruch R, Brik R. Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome. Seminars in Arthritis and Rheumatism. 2016; 45(4): 471-474. https://doi.org/10.1016/j.semarthrit.2015.07.005

  17. Slobodnick A, Shah B, Krasnokutsky S, Pillinger M. Update on colchicine. Rheumatology. 2017; 57(1): 4-11. https://doi.org/10.1093/rheumatology/kex453

  18. Dubey K, Kumar P, Labrou N, Shukla P. Biotherapeutic potential and mechanisms of action of colchicine. Critical Reviews in Biotechnology. 2017; 37(8): 1038-1047.https://doi.org/10.1080/07388551.2017.1303804

  19. Abbott C, Xu R, Sigal S. Colchicine-Induced Hepatotoxicity. ACG Case Reports Journal. 2017; 4: 120-123. https://doi.org/10.14309/crj.2017.120

  20. Ben-Chetrit E. Colchicine. Textbook of Autoinflammation. 2019. https://doi.org/10.1007/978-3-319-98605-0_40

  21. Bueno L, Paiva D, Carvalho P. Síndrome PFAPA: Diagnóstico e Tratamento na Atenção Primária à Saúde. Revista Brasileira de Medicina de Família e Comunidade. 2019; 14(41). https://doi.org/10.5712/rbmfc14(41)1815

  22. Cabras M, Carrozzo M, Gambino A, Broccoletti R, Sciascia S, Baldovino S et al. Value of colchicine as treatment for recurrent oral ulcers: A systematic review. Journal of Oral Pathology & Medicine. 2020. https://doi.org/10.1111/jop.13020

  23. Manthiram K, Li S, Hausmann J, Amarilyo G, Barron K, Kim H et al. Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Rheumatology International. 2017; 37(6): 883-889. https://doi.org/10.1007/s00296- 017-3688-3

  24. Vanoni F, Theodoropoulou K, Hofer M. PFAPA syndrome: a review on treatment and outcome. Pediatric Rheumatology. 2016; 14(1). https://doi.org/10.1186/s12969-016-0101-9

  25. Dusser P, Hentgen V, Neven B, Koné-Paut I. Is colchicine an effective treatment in periodic fever, aphtous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome?. Joint Bone Spine. 2016; 83(4): 406-411. https://doi.org/10.1016/j.jbspin.2015.08.017

  26. Gunes M, Cekic S, Kilic S. Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants?. Pediatrics International. 2017; 59(6): 655-660. https://doi.org/10.1111/ped.13265

  27. Hausmann J, Guven B, Anderson E, Dedeoglu F. Predicting Colchicine Response In Patients With Undefined Autoinflammatory Diseases. Arthritis Rheumatol. 2017; 69 (4).

  28. Papa R, Rusmini M, Volpi S, Caorsi R, Picco P, Grossi A et al. Next generation sequencing panel in undifferentiated autoinflammatory diseases identify patients with colchicine-responder recurrent fevers. Rheumatology. 2020; 59(2): 344-360. https://doi.org/10.1093/rheumatology/kez270

  29. Ozen S, Kone-Paut I, Gül A. Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments. Seminars in Arthritis and Rheumatism. 2017; 47: 115-120. https://doi.org/10.1016/j.semarthrit.2017.03.006

  30. Ben-Zvi I, Kukuy O, Giat E, Pras E, Feld O, Kivity S et al. Anakinra for Colchicine-Resistant Familial Mediterranean Fever: A Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis & Rheumatology. 2017; 69(4): 854-862.https://doi.org/10.1002/art.39995

  31. Grimwood C, Kone-Paut I, Piram M, Rossi-Semerano L, Hentgen V. Health-related quality of life in children with PFAPA syndrome. Orphanet Journal of Rare Diseases. 2018; 13(1). https://doi.org/10.1186/s13023- 018-0878-3

  32. Kadhim C, Maiolini F, Cerrito L, Sicignano L, Giovinale M, Verrecchia E et al. Colchicine trial in PFAPA Syndrome and MEFV-negative patients. Pediatric Rheumatology. 2015; 13(1). https://doi.org/10.1186/1546-0096-13-S1-O5

  33. Batu E, Batu H. Recurrence of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome after tonsillectomy: case-based review. Rheumatology International. 2019; 39(6): 1099- 1105. https://doi.org/10.1007/s00296-019-04310-y




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