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2020, Número 4

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Rev Hematol Mex 2020; 21 (4)


Ruxolitinib como tratamiento contra el COVID-19 en población mexicana

Ovilla-Martínez R, Cota-Rangel X, De La Peña-Celaya JA, Molina-Jaimes A, Alvarado-Zepeda MA, Rojas-Vértiz CKE, Araujo-Martínez NI, Ruiz-Luján R, Ortiz-Arroyo A, Báez-Islas PE

Idioma: Ingles.
Referencias bibliográficas: 29
Paginas: 195-204
Archivo PDF: 762.89 Kb.


RESUMEN

Antecedentes: Varias de las citocinas elevadas en COVID-19 son generadas por la vía de JAK/STAT. Los inhibidores de JAK se han propuesto como tratamiento contra la infección por SARS-CoV-2 moderada a severa.
Objetivos: Medir los cambios clínicos mediante la escala ordinal de 8 puntos; el objetivo secundario fue determinar los días de hospitalización, cambios en estados proinflamatorios, progresión a UCI, ventilación mecánica, defunciones y eventos adversos.
Material y Método: Estudio de serie de casos y controles tratados con ruxolitinib mediante uso compasivo en pacientes con neumonía por SARS-CoV-2.
Resultados: Se analizaron 10 casos con neumonía por COVID-19 tratados con ruxolitinib con escala inicial de 8 puntos de 5 en 9/10 y 6 en 1/10 en comparación con 10 controles con 5 en 9/10 y 6 en 1/10 pacientes. Al final todos los pacientes con ruxolitinib tenían menos de dos puntos, mientras que 3 pacientes del grupo control murieron. El tiempo de hospitalización fue menor en el grupo intervenido. No se reportaron eventos adversos graves en el grupo de casos.
Conclusiones: Los pacientes tratados con ruxolitinib tuvieron mejor evolución clínica y menor tiempo de hospitalización sin mayor toxicidad. Estos resultados preliminares deberán continuar con ensayos clínicos mayores.


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