medigraphic.com

2003, Número 4

Arch Cardiol Mex 2003; 73 (4)


El 17ß-estradiol modula los efectos de los cambios de la contractilidad vascular producidos por la insulina

Nava P, Carbó R, Guarner V

Idioma: Inglés
Referencias bibliográficas: 45
Paginas: 253-260
Archivo PDF: 101.09 Kb.


RESUMEN

Los estrógenos protegen a la mujer contra enfermedades vasculares periféricas y centrales; sin embargo, su papel se pierde con la diabetes. Los estrógenos reducen la tensión en las arterias mediante cambios en el calcio intracelular en células endoteliales y musculares lisas y la regulación de la óxido nítrico sintasa en células endoteliales. La insulina incrementa la liberación de endotelina-1 (ET-1) en células endoteliales aumentando la fuerza generada por las arterias. En este estudio se examina si el 17b-estradiol (E2b) modula los cambios en la contractilidad inducidos por insulina en las arterias femorales y coronarias. Las arterias se obtuvieron de ratas Wistar macho y se colocaron en cámaras para tejido aislado para perfundirse in vitro con distintas concentraciones de insulina y estrógenos estimulando la contracción con KCl 40 mmol/L. La insulina elevó la fuerza de la contracción inducida por KCl. Este incremento desapareció cuando se eliminó el endotelio. El E2b disminuyó la tensión desarrollada por las arterias conforme se aumentó la dosis y el efecto desapareció al quitar el endotelio. El incremento en la tensión por insulina disminuyó con E2b. En conclusión el efecto de la insulina sobre las arterias femorales y coronarias se encuentra modulado por el E2b.

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