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>Revistas >Revista Latinoamericana de Microbiología >Año 2006, No. 2


Miranda RJ
El gran mundo de los RNAs pequeños
Microbiología 2006; 48 (2)

Idioma: Español
Referencias bibliográficas: 45
Paginas: 73-78
Archivo PDF: 94.63 Kb.


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RESUMEN

En la última década se han descubierto en muchos organismos una gran cantidad de RNAs cuya función es la de servir como elementos regulatorios de la expresión genética y no codifican para una proteína. A estos RNAs se les denomina ncRNAs o sRNAs (non coding o small RNAs, RNAs no codificantes o pequeños, por sus siglas en inglés). De los más de 70 sRNAs que se han documentado en Escherichia coli, algunos regulan la traducción o estabilidad de los mRNAs, otros poseen actividades catalíticas y unos más modifican la actividad de una proteína. En esta revisión se discutirán los mecanismos de acción de algunos de ellos, así como los esfuerzos para encontrar nuevos sRNAs por medio de búsquedas sistemáticas.


Palabras clave: RNAs regulatorios, E. Coli.


REFERENCIAS

  1. Altuvia, S., D. Weinstein-Fischer, A. Zhang, L. Postow & G.Storz. 1997. A small stable RNA induced by oxidative stress: Role as a pleiotropic regulator and antimutator. Cell 90:43-53.

  2. Argaman, L., R. Hershberg, J.Vogel, G. Bejerano, E.G.H. Wagner, H. Margalit & S. Altuvia. 2001. Novel small RNA-encoding genes in the intergenic region of Escherichia coli. Curr. Biol. 11:941-950.

  3. Batey, RT, S.D. Gilbert, & R.K. Montange. 2004. Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine. Nature 432: 411-415.

  4. Chen S, E.A. Lesnik, T.A. Hall, R. Sampath, R.H. Griffey, D.J. Ecker & L.B. Blyn. 2002. A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome. Biosystems 65:157-177.

  5. Chen S., A. Zhang, L.B. Blyn & G. Storz. 2004. MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli. J. Bacteriol. 186:6689-6697.

  6. Cromie, M.J., Y. Shi, T. Latifi & E.A. Groisman. An RNA sensor for intracellular Mg2+. 2006. Cell 125:71-84.

  7. Fuchs R.T., F.J. Grundy & T.N. Henkin. 2006. The SMK box is a new SAM-binding RNA for translational regulation of SAM synthetase. Nat. Struct. Mol. Biol. 13:226-233.

  8. Geissman T.A. & D. Touati. 2004. Hfq, a new chaperoning role: Binding to messenger RNA determines access for small RNA regulator. EMBO J. 23:396-405.

  9. Gelfand, M.S., A.A. Mironov, J. Jomantas, Y.I. Kozlov & D.A. Perumov. 1999. A conserved RNA structure element involved in the regulation of bacterial riboflavin synthesis genes. Trends Genet. 15:439-442.

  10. Gopalan V., A. Vioque & S. Altman. 2002. RNase P: variations and uses. J. Biol. Chem. 277:6759-6762.

  11. Grundy F.J. & T.M. Henkin. 1998. The S box regulon: a new global transcription termination control system for methionine and cysteine biosynthesis genes in gram-positive bacteria. Mol. Microbiol. 30:737-749.

  12. Herskovits A.A., E.S. Bochkareva & E. Bibi. 2000. New prospects in studying the bacterial signal recognition particle pathway. Mol. Microbiol. 38:927-939.

  13. Johansson, J., P. Mandin, A. Renzoni, C. Chiaruttini, M. Springer & P. Cossart. 2002. An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes. Cell 110:551-556.

  14. Kawano M., A.A. Reynolds, J. Miranda-Rios & G. Storz. 2005. Detection of 5’- and 3’ UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli. Nucleic Acids Res. 33: 1040-1050.

  15. Kubodera T., M. Watanabe, K. Yoshiuchi, N. Yamashita, A. Nishimura, S. Nakai, K. Gomi & H. Hanamoto. 2003. Thiamine- regulated gene expression of Aspergillus oryzae thiA requires splicing of the intron containing a riboswitch-like domain in the 5'-UTR. FEBS Lett. 555:516-520.

  16. Majdalani N., C. Cunning, D. Sledejski, T. Elliot & S. Gottesman. 1998. DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription. Proc. Natl. Acad. Sci. 95:12462- 12467.

  17. Majdalani N., S. Chen, J. Murrow, K. St. John & S. Gottesman. 2001. Regulation of RpoS by a novel small RNA: the characterization of RprA. Mol. Microbiol. 39:1382-1394.

  18. Majdalani N., D. Hernandez & S. Gottesman. 2002. Regulation and mode of action of the second small RNA activator of RpoS translation, RprA. Mol. Microbiol. 46:813-826.

  19. Mandal, M., M. Lee, J.E. Barrick, Z. Weinberg, G.M. Emilsson, W.L. Ruzzo & R.R. Breaker. 2004. A glycine-dependent riboswitch that uses cooperative binding to control gene expression. Science 306:275-279.

  20. Masse E. & S. Gottesman. 2002. A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli. Proc. Natl. Acad. Sci. 99:4620-4625.

  21. Mikulecki P.J., M.K. Kaw, C.C. Brescia, J.C. Takach, D.D. Sledjeski & A.L. Feig. 2004. Escherichia coli Hfq has distinct interaction surfaces for DsrA, rpoS and poly(A) RNAs. Nat. Struct. Mol. Biol. 11:1206-1214.

  22. Miranda-Rios J., C. Morera, H. Taboada, A. Davalos, S. Encarnacion, J. Mora & M. Soberon. 1997. Expression of thiamin biosynthetic genes (thiCOGE) and production of symbiotic terminal oxidase cbb3 in Rhizobium etli. J Bacteriol. 179:6887- 6893.

  23. Miranda-Rios, J., M. Navarro & M. Soberon. 2001. A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria. Proc. Natl. Acad. Sci. 98:9736-9741.

  24. Mizuno T., M.-Y. Chou & M. Inouye. 1984. A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA). Proc. Natl. Acad. Sci. 81:1966-1970.

  25. Nahvi, A., N. Sudarsan, M.S. Ebert, X. Zou, K.L. Brown & R.R. Breaker. 2002. Genetic control by a metabolite binding mRNA. Chem. Biol. 9:1043-1049.

  26. Opdyke J.A., J.-G. Kang & G. Storz. 2004. GadY, a small- RNA regulator of acid response genes in Escherichia coli. J. Bacteriol. 186:6698-6705.

  27. Rivas E., R.J. Klein, T.A. Jones & S.R. Eddy. 2001. Computational identification of non-coding RNAs in E. coli by comparative genomics. Curr. Biol. 11:1369-1373.

  28. Romeo T. 1998. Global regulation by the small RNA-binding proteion CsrA and the non-coding RNA molecule CsrB. Mol. Microbiol. 29:1321-1330.

  29. Sauter C., J. Basquin & D. Suck. 2003. Sm-like proteins in eubacteria: the crystal structure of the Hfq protein from Escherichia coli. Nucleic Acids Res. 31:4091-4098.

  30. Schumacher M.A., R.F. Pearson, T. Moller, P. Valentin-Hansen & R.G. Brennan. 2002. Structures of a pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Smlike protein. EMBO J. 21:3546-3556.

  31. Sledejski D.D., A. Gupta & S. Gottesman. 1996. The small RNA, DsrA, is essential for the low temperature expression of RpoS during exponential growth in Escherichia coli. EMBO J. 15:3993-4000.

  32. Stormo, G.D. & Y. Ji. 2001. Do mRNAs act as direct sensors of small molecules to control their expression? Proc. Natl. Acad. Sci. 98:9465-9467.

  33. Sudarsan, N., J.E. Barrick & R.R. Breaker. 2003.Metabolitebinding RNA domains are present in the genes of eukaryotes. RNA 9:644-647.

  34. Sudarsan, N., J.K. Wickiser, S. Nakamura, M.S. Ebert, & R.R. Breaker. 2003. An mRNA structure in bacteria that controls gene expression by binding lysine. Genes Dev. 17:2688-2697.

  35. Tjaden B., R.M. Saxena, S. Stolyar, D.R. Haynor, E. Kolker & C. Rosenow. 2002. Transcriptome analysis of Escherichia coli using high density oligonucleotide probe arrays. Nucleic Acids Res. 30:3732-3738.-

  36. Vogel J., V. Bartels, T.H. Tang, G. Churakov, J.G. Slagter-Jager, A. Huttenhofer & E.G.H. Wagner. 2003. RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria. Nucleic Acids Res. 31:6435- 6443.

  37. Wassarman K.M. & G. Storz. 2000. 6S RNA regulates E. coli RNA polymerase activity. Cell 101:613-623.

  38. Wassarman K.M., F. Repoila, C. Rosenow, G. Storz & S. Gottesman. 2001. Identification of novel small RNAs using comparative genomics and microarrays. Genes Dev. 15:1637-1651.

  39. Weilbacher, T., K. Suzuki, A.K. Dubey, X. Wang, S. Gudapatay, I. Morozov I, C.S. Baker, D. Georgellis, P. Babitzke & T. Romeo. 2002. A novel sRNA component of the carbon storage regulatory system of Escherichia coli. Mol. Microbiol. 48:657-670.

  40. Wilderman P.J., N.A. Sowa, P.C. Fitzgerald, S. Gottesman, U.A. Ochsner & M.L. Vasil. 2004. Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis. Proc. Natl. Acad. Sci. 101:9792-9797.

  41. Winkler, W., A. Nahvi, & R.R. Breaker. 2002. Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression. Nature 419:952-956.

  42. Winkler, W., A. Nahvi, A. Roth, J.A. Collins y R.R. Breaker. 2004. Control of gene expression by a natural metabolite-responsive ribozyme. Nature 428:281-286.

  43. Winkler, W.C. & R.R. Breaker. 2005. Regulation of bacterial gene expression by riboswitches. Annu. Rev. Microbiol. 59:487-517.

  44. Zhang A, S. Altuvia, A. Tiwari, L. Argaman, R. Hengge-Aronis & G. Storz. 1998. The oxyS regulatory RNA represses rpoS translation by binding Hfq (HF-1) protein. EMBO J. 17:6061-6068.

  45. Zhang, A., K.M. Wassarman, C. Rosenow, B.C. Tjaden, G. Storz & S. Gottesman. 2003. Global analysis of small RNA and mRNA targets of Hfq. Mol. Microbiol. 50:1111-1124.



>Revistas >Revista Latinoamericana de Microbiología >Año2006, No. 2
 

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