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2021, Number 1

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Cuba y Salud 2021; 16 (1)

Hepatic and hematological toxicity of carbamazepine in drug-resistant epilepsy and its relationship with clinical variables

Lorigados PL, Sarria KMA, Pavón FN, Morales CL, González FME, Valdés MY

Language: Spanish
References: 44
Page: 41-49
PDF size: 306.60 Kb.


ABSTRACT

Objective: to analyze the toxicity of carbamazepine (CBZ) in patients with EFR by evaluating the serum concentrations of this drug, as well as to measure blood chemistry and hematological variables and their relationship with clinical parameters such as: number of antiepileptic drugs, time of evolution and number of crises.
Methodical: 19 patients with EFR were studied. The concentration of CBZ was measured by high-performance liquid chromatography and by enzymatic and colorimetric method the hematological and blood chemistry variables, respectively.
Results: 42.11% of the patients showed slight toxicity to CBZ. There is a positive correlation between CBZ and gamma glutamyl transferase (GGT). There was a correlation between the evolution time and the leukocyte count (p≤0.03) in the female sex. In males, the number of drugs was positively correlated with uric acid (p≤0.0009), red cell count (p≤0.04), hemoglobin (p≤0.02) and hematocrit (p≤0.02).
Conclusions: These data support the presence of mild toxicity due to CBZ related to liver damage in a percentage of patients with EFR, which makes pharmacological monitoring important and necessary. New evidence is provided of the relationship between clinical variables, blood chemistry and hematological parameters in these patients.


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