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2002, Number 4

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Bioquimia 2002; 27 (4)

Metrology
Guide for estimation of uncertainty measurement in clinical laboratory sciences

Fuentes AX, Sánchez MM
Full text How to cite this article

Language: Spanish
References: 12
Page: 112-120
PDF size: 139.88 Kb.


Key words:

Uncertainty of measurement, metrology, clinical laboratory report.

ABSTRACT

When measuring a quantity random and systematic errors can act together on the result producing an error of measurement (formerly called "total error") and generating a doubt — uncertainty— about the true value of the measured quantity. The International Organization for Standardization (ISO) defines uncertainty of measurement as a parameter, associated with the result of a measurement, that characterizes the dispersion of the values that could reasonably be attributed to the measurand (measured quantity). In other words, uncertainty is a numerical information that complements a result of measurement, indicating the magnitude of the doubt about this result.
The international scientific and standardization bodies recommend that the uncertainty of patients' results obtained in clinical laboratories should be known. By this reason, this article try to clarify the concept of uncertainty of measurement and to show the different approaches to estimate this parameter.


REFERENCES

  1. International Bureau of Weights and Measures, InternationalElectrotechnical Commission, International Organization forStandardization, International Organization of Legal Metrology,International Federation of Clinical Chemistry, International Union ofPure and Applied Chemistry and International Union of Pure andApplied Physics. International Vocabulary of Basic and General Termsin Metrology. ISO: Geneva, 1993.

  2. International Organization for Standardization, InternationalElectrotechenical Commission, International Organization of LegalMetrology, International Bureau of Weights and Measures. Guide tothe expression of uncertainty in measurement. Geneva: ISO, 1993.

  3. Ellison SRL, Rosslein M, Williamns A, dir. Quantifying uncertainty inanalytical measurements. 2nd. Ed. London: EURACHEM/CITAC; 2000.

  4. European Committee for Standardization. Medical informatics –Expression of the results of measurement in health sciences. ENV12435. Brusel·les: CEN, 1996.

  5. International Union of Pure and Applied Chemistry, InternationalFederation of Clinical Chemistry. Compendium of terminology andnomenclature of properties in clinical laboratory sciences [The SilverBook]. Oxford: Blackwell; 1995: 29.

  6. Fuentes-Arderiu X. Uncertainty of measurement in clinical laboratorysciences. Clin Chem 2000:46; 1437-8.

  7. Fuentes-Arderiu X. Influence quantities and uncertainty of measurement.Clin Chem 2001: 47; 1327-8.

  8. Fuentes-Arderiu X, Acebes-Frieyro, Gavaso-Navarro L, Castiñeiras-Lacambra MJ. Pre-metrological (pre-analytical) variation of somebiochemical quantities. Clin Chem Lab Med 1999; 37: 987-9.

  9. Perruchet C, Priel M. Estimación de la incertidumbre. Medidas y ensayos.Madrid: AENOR: 2001.

  10. McLaughlin MP. A compendium of common probability distributions.Version 2.3

  11. STATLETS™ User Manual-Glossary. Princeton, NJ: NWP Associates; 1997.

  12. Organización Internacional de Normalización. Laboratorios clínicos— Requisitos particulares sobre la calidad y la competencia. ISO15189. (Pendiente de publicación).




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Bioquimia. 2002;27