Domínguez-Gómez MA, Morales-Sánchez MA, Corona-Castillo PR, Salazar-Villegas KN, Reyes-Salcedo CA

Language: Spanish
References: 10
Page: 5-10
PDF size: 360.61 Kb.

ABSTRACT

Alopecia areata is as an autoimmune disorder, clinically characterized by hair loss in circular arrangement. It is classified into the non-scarring alopecias group. In order to initiate the correct treatment, it must be taken into account the extention and the anatomic areas affected at the time of diagnostic. When the disease affects greater than 50% of the scalp, and/or there are many areas involve, it is indicated to use phototherapy with topical or oral psoralen. Some authors have found positive results using this treatment in total and universal alopecia types, however, some others have found negative results in universal alopecia types. Patients treated with PUVAsol in the Phototherapy Unit of Centro Dermatológico "Dr. Ladislao de la Pascua", evolved favorably, with repopulation of almost 100%, so it can be concluded that, phototherapy as treatment for multiple and disseminated alopecia areata plates, it is a good treatment option. Nevertheless, it is required to perform more randomized clinical trials to know the real benefit of the PUVA therapy.

REFERENCES

1. Villasante-Fricke A, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015; 8: 397-403.

2. Martínez-Suárez H. Alopecia areata. Dermatol Rev Mex. 2015; 59: 395-405.

3. Lundin M, Chawa S. Gender differences in alopecia areata. J Drugs Dermatol. 2014; 13: 409-413.

4. Registro de Consulta Externa. Expediente Clínico Electrónico. Centro Dermatológico "Dr. Ladislao de la Pascua". Área de informática y estadística. Enero-Diciembre 2015.

5. Saceda-Corralo D, Grimalt R, Fernández-Crehuet P, Clemente A, Bernárdez C, García-Hernandez MJ et al. Beard alopecia areata: a multicenter review of 55 patients. J Eur Acad Dermatol Venereol. 2017; 31: 187-192.

6. Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update. Part II. Treatment. J Am Acad Dermatol. 2010; 62: 191-202.

7. Majumdar B, De A, Ghosh S, Sil A, Sarda A, Lahiri K, Chatterjee G, Das S. "Turban PUVAsol": a simple, novel, effective, and safe treatment option for advanced and refractory cases of alopecia areata. Int J Trichol. 2018; 10: 124-128.

8. Herz-Ruelas M, Gómez-Flores M, Miranda-Maldonado I, Welsh E, Ocampo-Candiani J, Welsh O. Escalating dosimetry of UVA-1 in the treatment of alopecia areata. Int J Dermatol. 2017; 56: 653-659.

9. El-Mofty M, Rasheed H, El-Eishy N, Hegazy RA, Hafez V, El-Samanoudy SI, Shaker O. A Clinical and immunological study of phototoxic regimen of ultraviolet A for treatment of alopecia areata: a randomized controlled clinical trial. J Dermatolog Treat. 2019; 30: 582-587.

10. Welsh O. Phototherapy for alopecia areata. Clin Dermatol. 2016; 34: 628-632.