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2021, Number 1

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Rev Cent Dermatol Pascua 2021; 30 (1)

Fixed erythema pigmentosum secondary to alopurinol ingestion

Villanueva OA, Ramírez GKM

Language: Spanish
References: 13
Page: 20-23
PDF size: 263.85 Kb.


ABSTRACT

Fixed pigmented erythema is a cutaneous reaction secondary to drugs intake, of which pathophysiology it isn't yet fully known. It is mainly associated with antibiotics intake, such as trimethoprim-sulfamethoxazole, NSAIDs, and psychotropic drugs. It's clinically characterized by erythematous-violet plaques that can occasionally appear edematous or with blisters, and resolve to leave a blue-gray hyperpigmented macules. Typically upon drug exposure, they appear in the same location. In this article, we report the case of a 38 years old male patient with disseminated erythematous-violet spots, in who diagnosis of fixed pigmented erythema secondary to allopurinol intake was made.


REFERENCES

  1. Fitzpatrick TB. Dermatology in general medicine. Chapter 41 Cutaneous reactions to drugs. New York: McGraw Hill. 2012, pp. 449-450.

  2. Muñoz EVF, Valenzuela PGA, Rochín TM. Estudio de 372 casos de eritema fijo pigmentario. Piel. 2011; 26: 213-220.

  3. Avilés IJA, Huerta BM, Suárez FR, Lázaro OP. Exantema fijo medicamentoso. Med Integral. 2002; 40: 251-255.

  4. Atzori L, Pinna AL, Mantovani L, Ferreli C, Pau M, Mulargia M et al. Cutaneous adverse drug reactions to alopurinol: 10 year observational survey of the dermatology department--Cagliari University (Italy). J Eur Acad Dermatol Venereol. 2012; 26: 1424-1430.

  5. Lee HJ, Kim HS, Park YM, Kim HO, Lee JY. Fixed drug eruption due to allopurinol: positive oral provocation. Ann Dermatol. 2011: 23: 402-403.

  6. Muñoz EVF, Rubio RMZ, Douriet MFA, Domínguez CG. Eritema pigmentado fijo atípico por diaminodifenilsulfona. Bol Med UAS. 2006; 2: 36-39.

  7. Tsai TF, Yeh TY. Allopurinol in dermatology. Am J Clin Dermatol. 2010; 11: 225-232.

  8. Sehgal VN, Jain S. Allopurinol induced transitory giant fixed drug eruption: an atypical expression. J Dermatol. 1999; 26: 198-199.

  9. Muñoz EVF, Valenzuela PGA. Eritema pigmentado fijo genital. Estudio de 69 casos. Rev Cent Dermatol Pascua. 2011; 20: 91-99.

  10. Gupta R. Drugs causing fixed drug eruptions: confirmed by provocation test. Indian J Dermatol Venereol Leprol. 2003; 60: 120-121.

  11. Kim MH, Shim EJ, Jung JW, Sohn SW, Kang HR. A case of allopurinol-induced fixed drug eruption confirme with a lymphocyte transformation test. Allergy Asthma Immunol Res. 2012; 4: 309-310.

  12. Calonje JE, Brenn T, Lazar A, Billings S. McKee's pathology of the skin. Cutaneous adverse reactions to drugs, Chapter 14, 4th ed. Elsevier. 2012, pp. 599-600.

  13. Schumacher M. Intravenous desensitization to allopurinol in a heart transplant patient with gout. Ann Allergy Asthma Immunol. 2004; 92: 374-376.




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