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2021, Number 4

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Acta Pediatr Mex 2021; 42 (4)

Effect of supplementation of selenium and zinc on IL-6, IL- 8, and TNF- α levels in cystic fibrosis pediatric patients

Camacho-Castillo LC, Medina-Torres EA, Pinzón-Navarro BA, Román-Casas M, González-Dorasco BM, Aguilar-Rodríguez E, Alva-Chaire AC, Cuevas-Schacht FJ, Carvajal-Aguilera KG

Language: Spanish
References: 27
Page: 155-162
PDF size: 485.66 Kb.


ABSTRACT

Background: Zinc and selenium are two micronutrients whose concentration is decreased in some cystic fibrosis patients; both minerals are involved in the regulation of the proinflammatory cytokines IL-6, IL-8 and TNF- α.
Objective: To determine the effect of Zn and Selenium supplementation on plasmatic levels of IL-6, IL-8, and TNF- α on cystic fibrosis patients.
Material and Methods: Pilot, comparative, longitudinal, experimental, prospective, prospective, uncontrolled, non-randomized study performed from October 2015 to October 2016. Cystic fibrosis patients aged 6 to 18 years, with exocrine pancreatic insufficiency and nutritional support for more than 6 months were included. Zinc 30 mg per day and selenium 200 mcg per day were given for 12 months. Plasma concentrations of IL-6, IL-8 and TNF- α at baseline, 6 and 12 months of supplementation were determined by ELISA.
Results: IL-6 basal levels, at 6 and 12 months after supplementation were 13.1 pg/mL, 15.3 pg/mL y 11.5 pg/mL respectively. For IL-8 were 38.7 pg/mL, 41.1 pg/mL, 41.7 pg/ mL, and for TNF- α 16.0 pg/mL, 18.8 pg/mL y 16.1 pg/mL.
Conclusions: Oral supplementation with zinc and selenium at therapeutic doses could have beneficial effects on the interleukin-mediated inflammatory state in pediatric patients with cystic fibrosis. More patients need to be evaluated.


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