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2020, Number 4

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Rev Cubana Farm 2020; 53 (4)

Spatial distribution of antibiotics consumption and its relation with sociodemographic variables in Santiago de Cali

Castro EJ, Cuartas ADE, Martínez RDM, Márquez GMA

Language: Spanish
References: 29
Page: 1-21
PDF size: 800.75 Kb.


ABSTRACT

Introduction: The use of antibiotics is generally related with microbial resistance. For these drugs, there have been identified consumption patterns by geographic areas and even related socio-demographic variables. These aspects are unknown in Santiago de Cali, which limits the identification of drugs consumption in order to carry out effective interventions.
Objective: Do an spatial analysis on the antibiotics consumption in the towns from the data of the sales in drugstores in Santiago de Cali, and to establish an association with sociodemographic variables.
Methods: To determine the antibiotics consumption, it was used the daily dose defined per 1000 inhabitants x day, and the exploratory analysis of spatial data. For the relation analysis, it was made the multiple linear regression by models validation. It was carried out a geographically weighted regression and the generated models were mapped. The analysis units were each of the towns in Santiago de Cali and the population belonging to the drugstores of each town. There were analysed 19 socio-demographic variables.
Results: With the I of Moran and the C of Geary it was identified a spatial pattern of overall high consumption to the South of the city in the towns 18 and 22, which was associated with deaths by infectious diseases, inhabitants per drugstores and the Rom ethnia. It was found relation between the health institutions in the town, the number of inhabitants per subscriptions to the sewer system and a higher consumption. In addition, it was found an inverse association between the education level and consumption.
Conclusions: It is observed a spatial pattern of consumption associated to sociodemographic variables that were not found in other studies. These results can support the development of interventions that reduce antibiotics consumption in the towns, the risk of their inappropriate use and other consequences as bacterial resistance.


REFERENCES

  1. Hicks LA, Bartoces MG, Roberts RM, Suda KJ, Hunkler RK, Taylor TH, et al. US Outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011. CID. 2015;60(9):1308-16. DOI: 10.1093/cid/civ076

  2. McDonnell L, Armstrong D, Ashworth M, Dregan A, Malik U, White P. National disparaties in the relationship between antimicrobial resistance and antimicrobial consumption in Europe: an observational study in 29 countries. J Antimicrob Chemother. 2017;72:3199-3204. DOI:10.1093/jac/dkx248

  3. Klein EY, Van Boeckel TP, Martinez EM, Pant S, Gandra S, Levin SA, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. PNAS. 2018;115(15):E3463-E3470. DOI: 10.1073/pnas.1717295115

  4. Terahara F, Nishiura H. Fluoroquinolone consumption and Escherichia coli resistance in Japan: an ecological study. BMC Public Health. 2019;19;426:1-8. DOI: 10.1186/s12889- 019-6804-3

  5. Vander SRH, Elseviers MM, Ferech M, Blot S, Goossens H. European Surveillance of Antimicrobial Consumption (ESAC): Data Collection Performance and Methodology Approach. Br J Clin Pharmacol. 2004;58:419-28. DOI: 10.1111/j.1365-2125.2004.02164.x

  6. Versporten A, Bolokhovets G, Ghazaryan L, Abilova V, Pyshnik G, Spasojevic T et al. Antibiotic use in eastern Europe: a cross national database study in coordination with the WHO Regional Office for Europe. Lancet Infect Dis. 2014;14:381-87. DOI: 10.1016/S1473- 3099(14)70071-4

  7. Mor A, Froslev T, Thomsen RW, Oteri A, Rijnbeek P, Schink T, et al. Antibiotic use varies substantially among adults: a cross-national study from five European Countries in the ARITMO project. Infection. 2015;43:453-72. DOI: 10.1007/s15010-015-0768-8

  8. Ferrer P, Sabaté M, Ballarín E, Fortuny J, Rottenkolber M, Schmiel, et al. Sales of macrolides, lincosamides, streptogramins, and amoxicillin/clavulanate in the in-and outpatient setting in 10 European countries, 2007 – 2010. Springerplus. 2015;4(612):1-9. DOI: 10.1186/s40064-015-1398-4

  9. Franchi C, Sequi M, Bonati M, Nobili A, Pasina L, Bortolotti A, et al. Differences in outpatient antibiotic prescription in Italy´s Lombardy region. Infection. 2011;39:299-308. DOI: 10.1007/s15010-011-0129-1

  10. Piovani D, Clavenna A, Cartavia M, Bonati M. Antibiotic and anti-asthmatic drugs prescriptions in Italy: geographic patterns and socio-economic determinants at the district level. Eur J Clin Pharmacol. 2014;70:331-37. DOI: 10.1007/s00228-013-1615-4

  11. Frenk MS, Kit BK, Lukacs SL, Hicks LA, Qiuping Gu. Trends in the use of prescription antibiotics: NHANES 1999-2012. J Antimicrob Chemother. 2016;71(1):251-56. DOI: 10.1093/jac/dkv319

  12. Kliemann BS, Levin AS, Moura ML, Bozczowski I, Lewis JJ. Socioeconomic determinants of antibiotic’s Consumption in the State of Sao Paulo, Brazil: The effect of restricting over-the-counter sales. PLoS ONE. 2016;11(12):e0167885. DOI: 10.1371/journal.pone.0167885

  13. Castro EJ, Patiño CDA, Carabalí VMA. Estudio de Utilización de Antibióticos a partir de las ventas en Droguerías de una Comuna de Santiago de Cali (Colombia). Revista de la Organización de Farmacéuticos Ibero-Latinoamericanos. 2012 [acceso 24/04/2020];22(4):184-91. Disponible en: http://www.revistadelaofil.org/wpcontent/ uploads/2014/01/OFILn224.pdf.

  14. Castro EJ, Molineros GLF. Consumo de antibióticos a partir de las ventas en droguerías en Santiago de Cali, Colombia. Rev Cubana Farm. 2016 [acceso 07/08/2020];50(1). Disponible en: http://www.medigraphic.com/cgibin/ new/resumen.cgi?IDARTICULO=72064

  15. Marra F, Mak S, Chong M, Patrick D. The Relationship among Antibiotic Consumption, Socioeconómic factors and Climatic Conditions. Can J Infect Dis Med Microbiol. 2010 [acceso 14/08/2020];21(3):e99-e106. Disponible en: https://www.hindawi.com/journals/cjidmm/2010/965268/abs/.

  16. Masiero G, Filippini M, Ferech M, Goossens H. Socioeconomic Determinants of Outpatient Antibiotic use in Europe. Int Public Health. 2010 [acceso 06/09/2019];55:469- 478. Disponible en: https://link.springer.com/article/10.1007/s00038-010-0167-y

  17. Goyal MK, Johnson TJ. Chamberlain JM, Casper Ch, Simmons T, Alessandrini EA, et al. Racial and ethnic differences in antibiotic use for viral illness in emergency departments. Pediatrics. 2017;140(4):e20170203. DOI: 10.1542/peds.2017-0203

  18. Organización Panamericana de la Salud. Manual del Usuario del Sistema de Información Geográfica en Epidemiologia y Salud Pública. SIGEPI. Versión 1.26. Washington D.C.: OPS; mzo 2003.

  19. Fotheringham AS, Charlton ME, Brunsdon C. Geographically weighted regression: a natural evolution of the expansion method for spatial data analysis. Environment and Planning A. 1998 [acceso 27/12/2019];30:1905-27. Disponible en: https://journals.sagepub.com/doi/abs/10.1068/a301905.

  20. Castro EJ, Arboleda GJF, Samboni NPA. Prevalencia y determinantes de automedicación con antibióticos en una comuna de Santiago de Cali, Colombia. Rev Cubana Farm. 2014 [acceso 02/10/2019];48(1):43-54. Disponible en: http://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=53395

  21. Belkina T, Duvanova, Karbovskaja J, Duitjer TJ, Vlcek J. Antibiotic use practices of pharmacy staff: a cross-sectional study in Saint Petersburg, the Russian federation. BMC Pharmacology and toxicology. 2017;18:11.. DOI: 10.1186/s40360-017-0116-y

  22. Castro EJ, Molineros LF. Cualificación y experiencia de los vendedores de droguería para la dispensación de amoxicilina en una comuna de Santiago de Cali, Colombia. Revista Colombiana de Ciencias Químico Farmacéuticas 2018;47(1):53-70. DOI: 10.15446/rcciquifa.v47n1.70658

  23. Castro EJ, Minotta GLJ y Molina RDL. Conocimiento sobre antibióticos del personal de las droguerías y los habitants compradores de la comuna 15 de Santiago de Cali. Vitae. 2018 [acceso 25/06/2020];25(Supl 1). Disponible en: https://aprendeenlinea.udea.edu.co/revistas/index.php/vitae/issue/viewFile/3440/336#page =102

  24. Vindenes T, Beaulac KR, Daron S. The Legislative momentum of antimicrobial stewardship: an international perspective. Curr Treat Options Infect Dis. 2016;8(72). DOI: 10.1007/s40506-016-0072-x

  25. Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Dreser A, Leufkens HGM, Wirtz VJ. Impact of Over-the-Counter Restrictions of Antibiotic Consumption in Brazil and Mexico. PLoS ONE. 2013;8(10):e75550. DOI: 10.1371/journal.pone.0075550

  26. Tyrstrup M, Beckman A, Molstad S, Engstrom S, Lannering C, Melander E, et al. Reduction in antibiotic prescribing for respiratory tract infections in Swedish primary carea retrospective study of electronic patient records. BMC Infectious Diseases. 2016;16:709. DOI: 10.1186/s12879-016-2018-9

  27. Kurt H, Karabay O, Birengel S, Memikoglu O, Yilmaz Bozkurt G, Yalci A. Effects of legal antibiotic restrictions on Compsumption of broad-Spectrum beta-lactam Antibotiotcs, Glycopeptides and Amphotericin B. Chemotherapy. 2010;56:359-63. DOI: 10.1159/000321553

  28. Plachouras D, Antoniadou A, Giannitsioti E, Galani L, Katsarolis L, Kavatha D. et al. Promoting prudent use of antibiotics: the experience from of multifaceted regional campaign in Greece. BMC Public Health. 2014 [acceso 28/07/2020];14:866. Disponible en: https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-866.

  29. Fleming DKE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM et al. Prevalence of Inappropriate Antibiotic prescriptions among US ambulatory care visits, 2010-2011. JAMA. 2016;315(17):1864-1873. Disponible en: https://www.alliantquality.org/sites/default/files/Fleming%20outpt%20abx%20JAMA%20 2016.pdf




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