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NCT Neumología y Cirugía de Tórax

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Antes Revista del Instituto Nacional de Enfermedades Respiratorias

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2021, Number 2

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Neumol Cir Torax 2021; 80 (2)

Thoracic air leak syndrome due to graft-versus-host disease after allogeneic bone marrow transplantation

Montero-Ureña RE, Contreras-Rodríguez FJ, Márquez-Barajas J, Anaya-Gómez FJ, García-González LA, Valdez-Rojas L, Garnica-Vázquez JJ, Jiménez-Tornero J, Díaz-Alba A, Luna-González CA, Álvarez-González MG, García-Valadez Y, Solano-Genesta M
Full text How to cite this article 10.35366/100993

DOI

DOI: 10.35366/100993
URL: https://dx.doi.org/10.35366/100993

Language: Spanish
References: 9
Page: 118-121
PDF size: 1162.66 Kb.


Key words:

Thoracic air leak syndrome, graft versus host disease, allogeneic bone marrow transplantation, anti-Ro52.

ABSTRACT

Introduction: Currently, hematopoietic stem cell transplant (HSCT) is a treatment for hematological neoplasms. Graft-versus-host disease (GVHD) is a complication of HSCT, pulmonary involvements are frequent, among them is thoracic air leak syndrome (SFAT). Clinical case: 22-year-old male with acute myeloblastic leukemia (AML), post allogeneic HSCT (HPT). In those who are admitted for recurrent spontaneous pneumothorax, infectious processes are ruled out and biopsies are taken with reports compatible with GVHD. Treatment was by endopleural catheter and bilateral pleurodesis, with adequate resolution of the condition after the latter. Conclusion: SFAT is a rare and late non-infectious lung complication of HPT, characterized by spontaneous pneumothorax. Which is associated with a poor forecast.


REFERENCES

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  7. Namkoong H, Ishii M, Mori T, Sugiura H, Tasaka S, Sakurai M, et al. Clinical and radiological characteristics of patients with late-onset severe restrictive lung defect after hematopoietic stem cell transplantation. BMC Pulm Med. 2017;17(1):123. Available in: https://doi.org/10.1186/s12890-017-0466-7

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Neumol Cir Torax. 2021;80