Adame MG, Flores OJ, López SMP, Muñoz HH, Velázquez MR, Miranda GA, Guzmán PMG, Salas AJC

Language: Spanish
References: 9
Page: s48-57
PDF size: 506.46 Kb.

ABSTRACT

The maculopapular rash is the most frequent manifestation related to the COVID-19 disease, unfortunately the rashes have been described in so many ways that the exact incidence is unknown. Most of the authors include morbilliform, maculopapular, erythematous-squamous, pityriasis rosea-like and polymorphous like erythema under this heading. In the last revision of the literature up to July of this year elaborated by Li, et al, the erythematous maculopapular exanthema is the most frequent manifestation of COVID-19 with 38.4% of the cases. In a surveillance study of positive tests in China, with 678 patients, erythematous rash accounted for 70% of skin lesions. The average age was 61.1 years, with similar involvement in both sexes. Maculopapular and morbilliform eruptions can be localized or disseminated, symmetrical or confluent. They start in the trunk and spread to the extremities. We still do not fully understand their pathophysiology, if all of them are directly associated with SARS-CoV-2, if some are reactions to drugs or if they are due to reactivation of other viruses.

REFERENCES

1. Li H, Zhao Y, Zhou L, Hu J. Cutaneous, skin histopathological manifestations and relationship to COVID-19 infection patients. Dermatol Ther. 2020; 33 (6): e14157. doi: 10.1111/dth.14157.

2. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382 (18): 1708-1720.

3. Catala A, Galván-Casas C, Carretero-Hernández G, Rodríguez-Jiménez P, Fernández-Nieto D, Rodríguez-Villa A et al. Maculopapular eruptions associated to COVID-19: A subanalysis of the COVID-Piel study. Dermatol Ther. 2020; 33 (6): e14170. doi: 10.1111/dth.14170.

4. Gianotti R, Recalcati S, Fantini F, Riva C, Milani M, Dainese E et al. Histopathological study of a broad spectrum of skin dermatoses in patients affected or highly suspected of infection by COVID-19 in the northern part of Italy: analysis of the many faces of the viral-induced skin diseases in previous and new reported cases. Am J Dermatopathol. 2020; 42 (8): 564-570.

5. Gisondi P, PIaserico S, Bordin C, Alaibac M, Girolomoni G, Naldi L. Cutaneous manifestations of SARS-CoV-2 infection: a clinical update. J Eur Acad Dermatol Venereol. 2020; 34 (11): 2499-2504. doi: 10.1111/jdv.16774.

6. Sachdeva M, Gianotti R, Shah M, Bradanini L, Tosi D, Veraldi S et al. Cutaneous manifestations of COVID-19: report of three cases and a review of literature. J Dermatol Sci. 2020; 98 (2): 75-81. doi: 10.1016/j.jdermsci.2020.04.011.

7. Drago F, Ciccarese G, Gasparini G, Cogorno L, Javor S, Toniolo A et al. Contemporary infectious exanthems: an update. Future Microbiol. 2017; 12: 171-193. doi: 10.2217/fmb-2016-0147.

8. Muzumdar S, Rothe MJ, Grant-Kels JM. The rash with maculopapules and fever in adults. Clin Dermatol. 2019; 37 (2): 109-118.

9. Tang K, Wang Y, Zhang H, Zheng Q, Fang R, Sun Q. Cutaneous manifestations of the Coronavirus Disease 2019 (COVID-19): a brief review. Dermatol Ther. 2020; 33 (4): e13528. doi: 10.1111/dth.13528.