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2021, Number 4

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Rev Fac Med UNAM 2021; 64 (4)

How to suspect patients with innate immunity errors at the first level of care?

Mondragón PAI, Scheffler MSC
Full text How to cite this article

Language: Spanish
References: 8
Page: 41-46
PDF size: 241.25 Kb.


Key words:

Primary immunodeficiency, warning signs, immunoglobulins, lymphopenia, education.

ABSTRACT

Currently there are 430 primary immunodeficiencies (PIDs) also called innate immunity errors, resulting from more than 320 identified mutations, which together affect at least 1 in 500 live newborns and are therefore no longer considered rare diseases.
Many doctors do not suspect these pathologies, which generates delay in diagnosis and treatment, generating a poor prognosis for life quality and death, for which reason the objective of this article is to transmit the key points for their suspicion and reference to a specialized center.


REFERENCES

  1. Aghamohammadi A, Abolhassani H, Kutukculer N, Wassilak S. Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication. Frontiers of Immunology. 2017 Jun 13;8:685.

  2. Tangye S, Al-Herz W, Bousfiha A. Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee. Journal of Clinical Immunology. 2020:4:24-64.

  3. Modell V, Orange J, Quinn J. Global report on primary immunodeficiencies: 2018 update from the Jeffrey Modell Centers Network on disease classification, regional trends, treatment modalities, and physician reported outcomes. Immunologic Research. 2018:66(3):367-380.

  4. Hughes H, Kahl L. Manual Harriet Lane de Pediatría. Vigésima primera edición. Elsevier: 2018.

  5. Condino-Neto A, Sorensen R, Gómez Raccio A, King A. Current state and future perspectives of the Latin American Society for Immunodeficiencies (LASID). Allergologia et immunopathologia. Sep-Oct 2015;43(5):493-7.

  6. Costa-Carvalho B, González-Serrano M, Espinosa Padilla S, Segundo G. Latin American Challenges with the Diagnosis and Treatment of Primary Immunodeficiency Diseases. Expert Review of Clinical Immunology. 2017 May;13(5):483-489.

  7. Bustamante JC, Partida A, Aldave JC, Álvarez A. Latin American consensus on the supportive management of patients with severe combined immunodeficiency. Journal of allergy and Clinical Immunology. 2019 Oct;144(4):897- 905.

  8. Seoane Reula ME, et al. Diagnóstico y manejo de las inmunodeficiencias primarias en niños. Protocolos diagnósticos y terapéuticos en pediatría. 2019;2:415-35.




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Rev Fac Med UNAM . 2021;64