Vargas AA, Cárdenas EE, Recio SM, Ocampo CJ

Language: Spanish
References: 17
Page: 168-175
PDF size: 597.15 Kb.

ABSTRACT

Background: 80% of the young population suffers from acne and 20% develops significant scars. Currently, there is no single treatment that is effective on its own for acne scars. TCAis the gold standard treatment of chemical peels. A method of TCA application at high concentrations has been reported, with excellent results.
Objective: To evaluate the clinical effect of focal application of 100% TCA. To determine the concordance amongst evaluators and patient satisfaction.
Methods: An experimental, prospective, comparative study was conducted, in which patients were their own control. They received a six course treatment with 100% TCA on scars on one side of the face, and with subsequent chemical exfoliation on the entire face with 25% TCA. Improvement was evaluated by the patient, and three different blinded dermatologists, based on photographs, which were taken at the initial and final visit. The following improvement scale was used according to the extension and size of the scar: excellent 70%, good 50-70%, moderate 30-50%, poor ‹30% and none 0%. The results were compared with non-parametric statistics.
Results: The median of the 25% TCA group was 1 (poor improvement) in comparison with the focal 100% TCA group, which showed a moderate improvement (median=2). The results are statistically significant according to chi-square (p= 0.004). There was a better concordance in the focal 100% TCA a group (kappa= 0.194 to 0.545) in comparison with the 25% TCA group.
Conclusions: The applied technique is simple, effective, affordable, and safe, according to our experience. The focal application of 100% TCA with subsequent chemical exfoliation with 25% TCA is more effective than applying chemical exfoliation with 25% TCA alone.

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