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2021, Number 2

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Alerg Asma Inmunol Pediatr 2021; 30 (2)

Stevens Johnson/toxic epidermal necrolysis overlap syndrome associated with hypogammaglobulinemia in the neonatal period: case report

Ramírez-Vásquez DG, Julián-García O, Ramírez-Cruz L, Martínez-Canseco R

Language: Spanish
References: 11
Page: 58-61
PDF size: 232.18 Kb.


ABSTRACT

The overlap of Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is an acute, rare drug reaction associated to a mortality rate of up to 29%. According to the widely accepted classification, the SJS/TEN overlap is considered an extensive manifestation of SJS, affecting between 10-30% of the body surface, presenting in the form of blisters and erosions caused mainly by drugs and infections. Case report: The case of a 1-month-old male patient is presented; at 12 days of age, he started showing generalized dermatosis with mucosal involvement characterized by blisters and blood crusts with a histopathological report of compatible superficial perivascular lymphocyte-pauciinflammatory vacuolar interface dermatitis along toxic epidermal necrolysis. Treatment using immunoglobulin was established at 2 g/kg/do, however, he later died of septic shock secondary to Candida albicans. Conclusion: SJS/TEN overlap is considered extremely rare in the neonatal period, it has few reported cases, so it should be considered within the differential diagnosis of bullous syndromes and therefore a skin biopsy shoud be performed in a timely manner.


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