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Federación Mexicana de Ginecología y Obstetricia, A.C.

2021, Number 10

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Ginecol Obstet Mex 2021; 89 (10)

Malignant Brenner tumor and pregnancy. Case report: Literature review

Loayza-Escalante ML, Cuadra-Espinilla M, Romero-Figueroa KB, Rodelgo-del Pino A, Sanz-García V, Bermejo- Aycart JI

Language: Spanish
References: 17
Page: 839-849
PDF size: 381.43 Kb.


ABSTRACT

Background: The association between Brenner tumor and pregnancy is extremely rare. Only four well-documented cases of benign Brenner tumor during pregnancy have been reported but nonmalignant.
Clinical case: A 33-year-old female patient, with a history of a pregnancy that ended in delivery and without setbacks, with no medical or surgical history of interest. In the ultrasound scan of the twelfth week, a 41 mm smooth-walled sonoluscent image was recorded in the left ovary. Lumpectomy was performed during cesarean section. Histological study described a transitional cell epithelial neoplasm, with benign, proliferative and infiltrative areas, compatible with a malignant Brenner tumor. She was treated with radical ovarian cancer surgery and adjuvant chemotherapy.
Conclusion: It is important to keep malignant Brenner's tumor in mind as a diagnosis of exclusion in the presence of rapidly and rapidly growing tumors during pregnancy. It is very important to evaluate the appendages in all follow-up ultrasounds during pregnancy.


REFERENCES

  1. Aggarwal P, Kehoe S. Ovarian tumors in pregnancy: A literature review. Eur J Obstet Gynecol Reprod Biol 2011; 155: 119-24. https://doi.org/10.1016/j.ejogrb. 2010.11.023

  2. Lyndon Hill ML, Connors-Beatty DJ, Nowak A, Tush B. The role of ultrasonography in the detection and management of adnexal masses during the second and third trimesters of pregnancy. Am J Obstet Gynecol 1998; 179 (3 pt 1): 703-7. https://doi.org/10.1016/S0002-9378(98)70068-7

  3. Leiserowitz GS, Xiling G, Cree R, et al. Adnexal masses in pregnancy: how often they are malignant? Gynecol Oncol 2005; 101: 315-21. https://doi.org/10.1016/j.ygyno. 2005.10.022

  4. Aoun F, Kourie HR, Sirtaine N, Hawaux E. Disappearance of upper urinary tract urothelial carcinoma after treatment of a borderline Brenner tumor: case report and literature review. Oncology Research and Treatment 2015; 38: 379- 81. https://doi.org/10.1159/000433488

  5. Uzan C, Dufeu-Lefebvre M, Fauvet R, et al. Management and prognosis of borderline ovarian Brenner tumors. International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society 2012; 22:1332-36. http://dx.doi.org/10.1097/ IGC.0b013e318267db2f

  6. Gedikbasi A, Ulker V, Aydin O et al. Brenner tumor in pregnancy: Clinical approach and pathological findings. J Obstet Gynaecol 2009. Res 35(3): 565-68. https://doi. org/10.1111/j.1447-0756.2008.00954.x

  7. Amor F, Vaccaro H, Alcázar JL, León M, Craig JM, Martínez J. Gynecologic Imaging Reporting and Data System. A New Proposal for Classifying Adnexal Masses on the basis of Sonographic Findings. J Ultrasound Med 2009; 28: 285-91. https://doi.org/10.7863/jum.2009.28.3.285

  8. Yang DM, Heller DS, Ganesh V, Gittens L. Brenner tumor of the ovary with extensive stromal luteinization presenting in pregnancy: Report of a case and review of the literature. J Matern Fetal Neonatal Med 2002; 12: 281-83. https://doi. org/10.1080/jmf.12.4.281.283

  9. Briggs ND, Katchy KC. Brenner tumor as encountered in the southern Nigerian Hospital. Int Gynaecol Obstet 1988; 27: 455-8. https://doi.org/10.1016/0020-7292(88)90130-0

  10. Beckmann CR. Brenner tumor during pregnancy. A case report. J Reprod Med 1983; 28: 681-3. PMID:6655629

  11. Condous G, Khalid A, Okaro E, Bourne T. Should we be examining the ovaries in pregnancy? Prevalence and natural history of adnexal pathology detected at first – trimester sonography. Ultrasound Obstet Gynecol 2004; 24: 62-4. https://doi.org/10.1002/uog.1083

  12. Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon, France: International Agency for Research on Cancer; 2014. World Health Organization Classification of Tumours; vol 6.

  13. Austin, RM, Norris, HJ., et al. Malignant Brenner tumor and transitional cell carcinoma of the ovary: a comparison. Int J Gynecol Pathol 1987, 6: 29-39. doi.10.1097/00004347- 198703000-00004

  14. Paalman RJ, Van Vliet PD. Brenner´s tumor with theca cell luteinization and hormonal function. Am J Obstet Gynecol 1969; 104: 1216-18. https://doi.org/10.1016/ S0002-9378(16)34298-3

  15. Gezginç K, Karatayli R, Yazici et al (2011) Malignant Brenner tumor of the ovary: analysis of 13 cases. Int J Clin Oncol 2012; 17: 324-29. https://doi.org/10.1007/s10147-011- 0290-7

  16. Han JH, Kim DY, et al. Intensive systemic chemotherapy is effective against recurrent malignant Brenner tumor of the ovary: an analysis of 10 cases within a single center. Taiwan. J Obstet Gynecol 2015; 54 (2): 178-82. https://doi. org/10.1016/j.tjog.2014.03.008

  17. Yingao Zhang, S. Allison Staley, et al. Malignant Brenner tumor of the ovary: Case series and review of treatment strategies. Gynecologic Oncology Reports 2019, 28: 29-32. https://doi.org/10.1016/j.gore.2019.02.003




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