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2021, Number 5

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Acta Pediatr Mex 2021; 42 (5)

PKU: Attention and executive profile in early detected and adequately treated patients

Pardo-Campos M, Enacan R, Valle G, Chiesa A

Language: Spanish
References: 29
Page: 233-240
PDF size: 213.33 Kb.


ABSTRACT

Background: Phenylketonuric patients, even properly diagnosed and treated, may result in neurocognitive dysfunction.
Objective: To evaluate neurocognition in phenylketonuric children and its relationship with disease variables and treatment.
Materials and Methods: Descriptive and comparative, expost-facto, cross-sectional, prospective study conducted from 2018 to 2019 in pediatric patients with phenylketonuria (group 1) aged 9 to 11 years and a control group of healthy children of the same age (group 2). All were assessed with a battery of tests for IQ and cognition.
Results: Thirty children with phenylketonuria (18 boys and 12 girls) (group 1) and 30 without phenylketonuria (group 2) were studied. The IQ of group 1 was normal, average and lower than that of group 2 (p ‹ 0.01) with lower executive control associated with impulsivity regulation, processing speed and divided and focused attention. In both groups, performance and verbal IQ were average normal, with significant differences in performance IQ, small effect size and no significant differences in verbal IQ.
Conclusion: Phenylketonuric children had repercussions in cognitive functions associated with executive and attentional control. They evidenced vulnerability of executive function related to disease control in childhood.


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