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2019, Number 3

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Rev Cubana Plant Med 2019; 24 (3)

Absence of antimicrobial activity in a lyophilized aqueous extract from Capraria biflora L. (goatweed)

Fuentes CI, Spengler SI, Leyva CV, Ferrer MY, García PTH

Language: Spanish
References: 15
Page: 1-10
PDF size: 312.05 Kb.


ABSTRACT

Introduction: the species Capraria biflora L., from the Scrophulariaceae family, has a long history of use in traditional medicine for the treatment of various disorders whose causes could be related to microbial infections.
Objective: determine the antimicrobial activity of lyophilized aqueous extract from the species Capraria biflora L. against a minimum set of microorganisms of clinical interest.
Methods: the extract was obtained by oven drying, pulverization in a mortar, decoction and lyophilization. In vitro antibacterial activity of the aqueous extract was evaluated at two concentrations (10 and 50 mg/ml) by the agar diffusion test with a minimum set of microorganism strains composed of four gram-negative bacteria: Klebsiella neumoneae (ATCC 10031), Salmonella tiphymurium (ATCC 14028), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), one gram-positive bacterium: Staphylococcus aureus (ATCC 6538), and two yeasts: Candida albicans (ATCC 10231) and Saccharomyces cerevisiae (BCTP 20/08/2008).
Results: at the study concentrations, the aqueous extract of Capraria biflora L. leaves does not display antimicrobial activity against the strains of microorganisms of clinical interest evaluated in the assay.
Conclusions: this is the first evaluation of the antimicrobial activity of lyophilized aqueous extract from leaves of Capraria biflora L. against strains of bacteria and fungi of clinical interest at concentrations of 10 and 50 mg/ml. No inhibitory effect was found. It is recommended to conduct further antimicrobial activity studies incorporating the topic of microbial virulence, aimed at evaluating the potential bacteriostatic effect of the study extract.


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