2002, Number 3
Rev Endocrinol Nutr 2002; 10 (3)
Godínez GSA, Marmolejo OGE, Márquez RE, Siordia VJJ, Baeza CR
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ABSTRACTHuman obesity is characterized by a wide variation in the distribution of excess body fat, and the distribution of fat affects the risks associated with obesity as well as the kinds of comorbidities that result. Central obesity is thus more strongly associated with comorbidities in various systems than is peripheral obesity. This is particularly evident when intra-abdominal, visceral depots are enlarged. Visceral obesity is, also associated with endocrine abnormalities, in cortisol, growth hormone and sex steroids dynamics, with a profound effect on peripheral tissues. Indeed, visceral obese individuals with the metabolic syndrome may have all hormonal abnormalities of the elderly, suggesting that this condition may be a sign of premature ageing.