2021, Number 6
Med Int Mex 2021; 37 (6)
León-Miranda AE, Lozano-Nuevo JJ, Ayala-San Pedro JA, Mendoza-Portillo E, Sánchez-Avilés TA, Velázquez-Navarrete KE
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ABSTRACTBackground: Acute kidney injury occurs frequently in patients with sepsis, so identifying risk factors may be useful to avoid this complication. One of factors that have charged interest is the level of chlorine.
Objective: To determine the association between hyperchloremia and the development of acute renal injury using negative chlorine delta as well as creatinine delta.
Materials and Methods: Fifty-six patients with sepsis (qSOFA ≥ 2), 28 with chlorine ≥ 110 (when admitted to the emergency room or at 72 h) and 28 with chlorine ‹ 110 were included. The chlorine delta and creatinine delta were analyzed establishing an improvement in the creatinine level with a negative creatinine delta ‹ 0.04 mg/dL. Two groups were established: patients with renal failure and without renal failure.
Results: An association was detected between the patients who observed hyperchloremia with the development of renal failure (p = 0.04). We obtained an OR of 7 with a 95%CI of 0.8 to 65. In Pearson’s correlation between delta chlorine and delta creatinine negative, a bilateral significance of 0.024 was obtained with an R of -0.3.
Conclusions: Acute renal injury is statistically significant associated with hyperchloremia in patients with sepsis compared with normochloremia.