2021, Number 6
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Med Int Mex 2021; 37 (6)
Acute osteolysis following hypercalcemia of malignancy
Andrade-Castellanos CA, Novas-Rojas Y, Gutiérrez-Ramírez FJ
Language: Spanish
References: 9
Page: 1103-1107
PDF size: 205.49 Kb.
ABSTRACT
Background: Acute hypercalcemia is a life-threatening condition that most commonly
results from malignancy. Local osteolytic hypercalcemia (the local destruction
of bone by tumor with calcium release) accounts for about 20% of cancer-related
hypercalcemia. Destruction of bone by metastatic cancer is a late event, starting when
tumor cells proliferate. Symptoms and complications of bone metastases (pain, pathologic
fractures, compression of the spinal cord) become more evident as the disease
becomes more extensive.
Clinical case: A 27-year-old female patient that developed acute osteolysis following
hypercalcemia of malignancy.
Conclusions: What makes the present case unique was the rapid evolution of
osteolysis during the hypercalcemic crisis, evidenced by computed tomography, in a
temporality of only 14 days.
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