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2021, Number 3

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Rev Mex Traspl 2021; 10 (3)

BK virus nephropathy in grafting biopsies in Veracruz

Luna-Salinas JA, Argüelles-Morales AD, Martínez-Mier G, Budar-Fernández LF

Language: Spanish
References: 17
Page: 79-85
PDF size: 270.56 Kb.


ABSTRACT

Introduction: BK virus nephropathy is an infectious pathology produced by the BK virus, also known as polyomavirus, which manifests in post-transplanted renal graft patients due to pharmacological immunosuppression, resulting in long-term damage and loss of the renal graft. Objective: To determine the prevalence of BK virus nephropathy in renal graft biopsies of recipients of the UMAE HE No. 14 "Adolfo Ruiz Cortines". Material and methods: Descriptive, observational and retrospective study in the Nephrology Service UMAE HE No. 14 "Adolfo Ruiz Cortines". Biopsied renal graft recipients older than 18 years were included. SV40 antigen positivity was determined and BK virus prevalence was calculated. Results: We considered 101 biopsies, 60 men, mean age 31.85 ± 10.67 years. The 85.14% received live graft. The prevalence of BK virus nephropathy was 8.91%. Induction therapy was: 45.54% basiliximab, 27.72% thymoglobulin and 26.73% methylprednisolone. For maintenance therapy the treatment was tacrolimus 51.48%, cyclosporine 34.65% and sirolimus 13.86%. Of the total number of SV40-positive patients, the induction treatment that most patients received was basiliximab in 66.66%, followed by thymoglobulin 22.22% and methylprednisolone 11.11%. Maintenance therapy in these cases was with cyclosporine 55.55% and tacrolimus 44.44%. A correlation between positive and negative patient variables was performed using χ2 and showed no significant statistical difference. Conclusions: The prevalence reported in this study is similar to that reported in other hospital centers.


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