Mascareñas SA, Vaquera AD, Luévanos GJC, Hernández SCA, García RF, O-Cavazos M, Castillo BJI

Language: Spanish
References: 10
Page: 179-182
PDF size: 205.63 Kb.

ABSTRACT

Introduction: In Mexico, screening for latent tuberculosis is not a systematized program. The objective was to evaluate the prevalence, incidence rate and risk factors for purified peptide derivative (PPD) conversion in a pediatric residency program in Nuevo Leon, Mexico. The objective was to evaluate the prevalence, incidence rate and risk factors for purified peptide derivative (PPD) conversion in a pediatric residency program in Nuevo Leon, Mexico. Material and methods: Cohort study, involving residents of a public hospital in Mexico, demographic and clinical data were collected. A PPD induration ≥ 10 mm was considered positive. PPD conversion was defined as a result ≥ 10 mm in students with a previous negative result. The Wilcoxon rank test was used and a logistic regression analysis was performed to measure the association of possible factors for PPD reactivity. The conversion rate was subjected to McNemar's test. Results: 99 students were followed up, 54% were female. The baseline prevalence of positive PPD was 21%. The prevalence of conversion was 25%. Conversion was higher (20.4%) in first-year residents. The conversion rate was 10.5/1,000 person-months, with a higher prevalence in first-year residents (13.6/1,000 person-months). The probability of presenting a baseline positive result was higher in students with previous exposure to a case of tuberculosis (OR; 3.36 [95% CI 1.3-8.2]). Conclusions: Our study identifies a high prevalence and incidence of PPD conversion in pediatric residents in Mexico. The design of more stringent preventive strategies is necessary to prevent tuberculosis infection in our population.

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