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ISSN 1561-3194 (Electronic)

2020, Number 4

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Rev Ciencias Médicas 2020; 24 (4)

Validation of a questionnaire on the interaction of genetic and environmental factors in the development of bronchial asthma

Orraca CO, Lardoeyt FR, Orraca CM

Language: Spanish
References: 19
Page: 1-17
PDF size: 388.88 Kb.


ABSTRACT

Introduction: bronchial asthma is the classic disease among allergic conditions, and has great impact on health worldwide. It is a complex disease both genetically and phenotypically, and genetic-environmental interactions make it even more complex.
Objective: to validate a questionnaire for the study of the involvement of genetic factors and their interaction with environmental factors in the onset of immune disorders due to bronchial asthma.
Methods: the study was developed in the Department of Immunology at Pepe Portilla Provincial Pediatric Teaching Hospital in Pinar del Río province. The coordinating group of the technique to be carried out was selected and comprised three professionals responsible for the proposed research. The Delphi Methodology was used, completing its four phases: definition of the topic, selection of experts, implementation of consultation rounds and assessment of results. To determine the agreement or similarities of the responses of the evaluators respectively, the Kendall and Friedman concordance coefficient was calculated.
Results: twenty-one (21) experts with high levels of competence were selected according to the calculation of the coefficients of knowledge and argumentation. In the third version of the questionnaire, there was similarity in the responses of the experts in favor of the higher category of Very Essential, as well as agreement in the level of response of the experts.
Conclusions: the designed questionnaire reaches optimal levels of content validity and feasibility to determine the contribution of genetic factors and their interaction with environmental factors on the onset of immune disorders due to bronchial asthma.


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