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2002, Number 6

Rev Fac Med UNAM 2002; 45 (6)

Physiology of reproduction: hormones and gonadotrophins

Prieto GB,Velázquez PM
Full text How to cite this article

Language: Spanish
References: 10
Page: 252-257
PDF size: 49.66 Kb.


Key words:

Hypothalamus, pituitary gland, ovary, testicle.

ABSTRACT

Reproduction in almost all animal species is regulated by a neuro-hormonal mechanism in both sexes that must be synchronized, through chemical changes in various parts, which begins to manifest with in the courting ritual. The follicular stimulating and lutein hormones from the pituitary gland produce the maturation of the gonads and steroid genesis. However, other hormones from the hypothalamus allow the pituitary gland to liberate gonadotrophins, GnRH which is a decapeptide that has been preserved from fish to humans. The regulating gene is located in chromosome 8. At first glance, this hormone appears to be generated by pulses that the steroids unlock in the hypothalamus. However, since is secreted in small quantity and has a short half-life, there have been suggestions that a local synthesis of the same hormone takes place in the receptor. Regulation of the reproduction system is controlled by a very complex mechanism. Further elements intervene in the system such as the GABA, endorphins dopamine, nora renaline and serotonin, as well as local non-steroidal elements such as inhibine and activine. As a spin-off, advances in the knowledge of this area have shown a clinical usefullness, illustrated by GnRH analogs which are used in the treatment of early puberty, ovarian cysts and endometriosis.


REFERENCES

  1. Albanese C, Colin I M, Crowley W F et al. The gonadotrophin genes: evolution of distinct mechanisms for hormonal control. Recent Progress in Hormone Res 1996; 51: 23-61.

  2. Conn PM. Ligand dimerization: a technique for assessing receptorreceptor interactions. Methods Enzimol. 1983; 103: 49-58.

  3. Conn PM. The molecular mechanism of gonadotrophin-releasin hormone action in the pituitary. In: The physiology of reproduction. Knobil E and Neill J.D. (editors) 2th ed. New York. Raven Press. 1994.

  4. De Roux N. A family with hypogonadotropic hypogonadism and mutations in the gonadotrophin-releasing hormone receptor. N. England J of Med 1997; 337: 1597-1602.

  5. Flanagan CA, Millar RP, Illing N. Advences in understanding gonadotrophin releasing hormone receptor structure and ligand interactions. Rev of Reproduction 1997; 2: 113-120.

  6. Jennes L, Eyigor O, Janovick JA, Conn PM. Brain gonadotrophin releasing hormone receptors: localization and regulation. Recent Progress in hormone Research 1997; 52: 475-491.

  7. Marshall JC, Griffin ML. The role of changing pulse frequency in the regulation of ovulation . Human reproduction. 1993; 8: 57-61.

  8. Sealfon SC, Weinstein H, Millar RP. Molecular mechanisms of ligand interaction with the gonadotrophin-releasing hormone receptor. Endocr Rev 1997; 18: 180-205.

  9. Vanecek J. Cellular mechanisns of melatonin action. Physiol Rev 1998; 78(3): 687-721.

  10. Yellon SM, Lehman MN, Newman SW. The gonadotrophin-releasing hormone neuronal system of the male Djungarian hamster: distribution from the olfatory tubercle to the medial basal hypothalamus. Neuroendrocr 1990; 51: 219-225.




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Rev Fac Med UNAM . 2002;45