Álvarez-Cienfuegos A, Cantero-Nieto L, García-Gómez JA, Martín J, Ortego-Centeno N

Language: Spanish
References: 0
Page: 22-29
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ABSTRACT

Objectives: To evaluate endothelin 1 (ET-1) serum levels in women with systemic sclerosis compared with healthy controls and to examine possible associations between ET-1 and markers of arterial stiffness.
Materials and Methods: A cross-sectional study was performed in San Cecilio Hospital, Granada, Spain, from November 2017 to May 2019. Women with systemic sclerosis and age and sex matched healthy controls were enrolled in this study. Pulse wave velocity was measured non-invasively along the carotid-femoral arterial segment. Serum ET-1 was analysed using indirect enzyme-linked immunosorbent assay (ELISA).
Results: Sixty-two women with systemic sclerosis and 62 healthy controls were included. There was a significant difference in ET-1 serum levels between systemic sclerosis women patients and healthy controls (p = 0.001). Serum levels of ET-1 were positively associated with pulse wave velocity (r = 0.26, p ‹ 0.05), within the study group.
Conclusions: ET-1 serum levels are associated with pulse wave velocity in women with systemic sclerosis. Therefore, drugs that block ET-1 may be effective in reducing large artery stiffness in women with systemic sclerosis, and thus cardiovascular risk.