Pedreáñez A, Mosquera J, Muñoz N, Tene D

Language: Spanish
References: 0
Page: 130-140
PDF size: 269.66 Kb.

ABSTRACT

Cardiovascular complications are the main cause of mortality and morbidity in diabetic patients, in whom changes in the structure and function of the myocardium have been described. Numerous molecular mechanisms to explain cardiac alterations in diabetes have been proposed. In this regard, angiotensin II (Ang II), a pro-inflammatory peptide that constitutes the main effector of the renin-angiotensin system (RAS) has taken a preponderant role. Classically the RAS has been defined as a complex system of enzymes, receptors and peptides that controls blood pressure and fluid homeostasis. However, in recent years, this concept has undergone substantial changes. Although this system has been known for decades, recent discoveries in cellular and molecular biology, as well as in cardiovascular physiology, have introduced greater knowledge about its function and its relationship to the development of diabetic cardiomyopathy. Therefore, the aim of this review is to analyze the role of Ang II in the different biochemical pathways that may be involved in the development of cardiovascular damage during diabetes.