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2022, Number 1

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Rev Mex Traspl 2022; 11 (1)

Evaluation of Donor Preservation Therapy in Brain Death guided by Therapeutic Goals of donors at the Hospital of specialties ''Dr. Antonio Fraga Mouret'' from the ''La Raza'' National Medical Center

Abarca-Romero JE, García-García BA, Maya-Rivera AL
Full text How to cite this article 10.35366/104328

DOI

DOI: 10.35366/104328
URL: https://dx.doi.org/10.35366/104328

Language: Spanish
References: 10
Page: 20-24
PDF size: 245.52 Kb.


Key words:

Transplant, brain death, preservation therapy, donor therapeutic goals, organ procurement organizations.

ABSTRACT

Organ transplantation represents the only definitive therapeutic option for patients with end-stage organ failure. This option has demonstrated its effectiveness and its positive impact on the health and economic systems. It is estimated that a multi-organ donor has the potential to benefit 7 or more recipients. Countries such as Spain and Portugal (with 30 to 40 donors per million inhabitants per year) have placed great importance on meeting the therapeutic goals of donors (MTD) during preservation therapy (PT) in Brain Death Donors (DME), all this due to the large number of complications inherent to this clinical condition that put the loss of these donors at risk. Although there is no established consensus of the BAT, there are proposals prepared by the Organ Procurement Organizations (OPOs) such as the United Network For Organ Sharing (UNOS) and the medical management forum to optimize the potential of the organ donor (Forum of Medical Management to Optimize Donor Organ Potential [FMMODOP], which have shown greater benefits with respect to the number of organs procured per donor. Because Mexico has a low donation rate (0.01 to 9.9 donors per million inhabitants), it is important that the management of DME is guided by the therapeutic goals proposed by the OPOs to avoid requesting organs that can be procured, considering the experience of the Hospital of specialties "Dr. Antonio Fraga Mouret" from the "La Raza" National Medical Center (HECMNR) in the area of cadaveric donation the present study seeks to evaluate the preservation therapy assigned to the DME in order to determine if the MTD established by the OPOs were achieved.


REFERENCES

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  2. Global Observatory on Donation and Transplantation. International Report on Organ Donation and Transplantation Activities Executive summary 2017. Disponible en: //www.transplant-observatory.org/wp-content/uploads/2019/11/glorep2017.pdf

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  8. Plurad DS, Bricker S, Neville A et al. Arginine vasopressin significantly increases the rate of successful organ procurement in potential donors. American J Surg. 2012; 204 (6): 856-861. Available in: https://doi.org/10.1016/j.amjsurg.2012.05.011

  9. Salim A, Martin M, Brown C et al. The Effect of a Protocol of Aggressive Donor Management: Implications for the National Organ Donor Shortage. The Journal of Trauma, Injury, Infection, and Critical Care. 2006; 61 (2): 429-435. doi: 10.1097/01.ta.0000228968.63652.c1.

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Rev Mex Traspl. 2022;11