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ISSN 1527-3172 (Electronic)

2020, Number 2

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MEDICC Review 2020; 22 (2)

Severe COVID-19 Cases: Is Respiratory Distress Partially Explained by Central Nervous System Involvement?

Machado-Curbelo C

Language: English
References: 4
Page: 38-39
PDF size: 26.81 Kb.


ABSTRACT

The main characteristics and challenging symptoms of COVID-19, caused by the novel coronavirus SARS-CoV-2, are related to respiratory distress. Although most patients have mild symptoms such as fever, headache, cough, myalgia and anosmia, some develop acute respiratory distress syndrome, leading to death in many cases.
Human coronavirus (CoVs) were responsible for two previous worldwide outbreaks: Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERSCoV). Several reports of these outbreaks demonstrated that these diseases affected the central nervous system (CNS).[1] Thus, for the current COVID-19 pandemic, a crucial question arises: does CNS affection at least partially explain the respiratory distress commonly found in these patients?


REFERENCES

  1. Machado C, Gutiérrez JV. Brainstem dysfunction in SARS-COV2 infection can be a potential cause of respiratory distress. Preprints [Internet]. 2020 [cited 2020 Apr 20]. 2020040330. DOI:10.20944/preprints202004.0330.v1). Available at: https://www.preprints.org/manuscript/202004.0330/v1

  2. Machado C, Gutiérrez JV. Anosmia and ageusia as initial or unique symptoms after SARS-COV-2 virus infection. Preprints [Internet]. 2020 [cited 2020 Apr 20]. 2020040272. DOI: 10.20944/preprints202004.0272.v1). Available at: https://www .preprints.org/manuscript/202004.0272/v1

  3. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet [Internet]. 2020 Feb 15 [cited 2020 Apr 15];395(10223):497-506. Available at: https:// www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

  4. Wang Z, Yang B, Li Q, Wen L, Zhang R. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Clin Infect Dis [Internet]. 2020 Mar 16 [cited 2020 Apr 16]. DOI: 10.1093/cid/ciaa272. [Epub ahead of print]. Available at: https://www.unboundmedicine.com/medline/citation/32176772/ Clinical_Features_of_69_Cases_with_Coronavirus_Disease_2019_in_Wu han_China_




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