Montero VD, Abarca BI, Chavarría RA

Language: Spanish
References: 15
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ABSTRACT

The glomerular filtration rate (GFR) is the product of the number of nephrons multiplied by the mean glomerular filtration rate of a single nephron. This measure in the elderly is conditioned by a series of factors that lead to the erroneous diagnosis of kidney disease, without taking into account the changes that the kidney undergoes with aging. The use of different endogenous markers such as creatinine is subject to the decrease in muscle mass and diet, however, its ease of measurement, its low cost and the wide availability of analysis, make it one of the most widely used in the clinical practice. Cystatin C is not affected by factors such as age, sex, race and muscle mass, so it is considered a better biomarker in geriatric patients, who have a great variability in their muscle composition. Currently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula is recommended by the latest Kidney Disease Improving Global Outcomes (KDIGO) guidelines of 2012 to estimate glomerular filtration rate. In addition, other CKD-EPI equations with cystatin C and CKD-EPI with creatinine-cystatin have been developed.

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