Montero VD, Abarca BI, Pacheco MM

Language: Spanish
References: 21
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ABSTRACT

The kidneys are one of the organs that undergoes the most changes during aging. There are a series of mechanisms involved in the renal senescence process that explain the structural, functional and molecular changes that occur intrinsically in this organ. One of the most studied is the Klotho gene, whose decrease favors harmful processes that lead to arteriosclerosis and the progression of permanent kidney damage. Other mechanisms detailed in this review include fibroblast growth factor 23, cellular senescence, telomere shortening, chronic inflammation, and Wnt signaling that is often overexpressed during aging. Understanding these mechanisms will favor the implementation of different interventions in the future to stop or slow down the fibrosis and sclerosis that develops in older adults with increasing age.

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