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Revista Mexicana de Anestesiología

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ISSN 0484-7903 (Print)
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2022, Number 3

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Rev Mex Anest 2022; 45 (3)

Acquired hemophilia A in pregnancy. Clinical case of critical medicine in obstetrics due to extreme morbidity and its perioperative transdisciplinary approach

Reyes-Mendoza LE, Castorena-de AR, Enríquez-López R, Ángeles-Vázquez MJ, Anaya-Herrera J, Flores-Cánovas Y, Sevilla-Cano A, Malagón-Reyes R, Rodríguez-Roldán M, Mendieta-Zerón H, Díaz LM, Carrillo-Esper R, Briones-Garduño JC
Full text How to cite this article 10.35366/105595

DOI

DOI: 10.35366/105595
URL: https://dx.doi.org/10.35366/105595

Language: Spanish
References: 6
Page: 202-206
PDF size: 250.24 Kb.


Key words:

Acquired hemophilia type A, critical obstetrics, activated partial thromboplastin time.

ABSTRACT

The identification of multiple risk factors that predispose to bleeding during the obstetric event, such as acquired hemophilia, which is a disorder that develops due to the generation of autoantibodies that inhibit coagulation factors, the objective interpretation of routine laboratory tests , the development of systematized thinking in diagnostic-therapeutic integration by health personnel, and the provision of hospital pharmacological resources, is what frequently determines the prognosis in obstetric patients with extreme morbidity who require multidisciplinary care in the different hospital units of the health sector of our country. The objective is to present a clinical case of extreme morbidity due to acquired hemophilia, its clinical presentation, evolution and fatal outcome. A case referred from another unit of the ISEM (Instituto de Salud del Estado de México) Health Sector, treated at the Obstetric Intensive Care Unit of the "Mónica Pretelini Sáenz" Hospital, is presented, highlighting the importance of diagnostic-therapeutic integration, and the multifactorial interaction of variables related to its fatal outcome. Conclusions: Ignorance of the pathology, delay in diagnosis, multiple conditioning procedures of iatrogenic hemorrhage and the limitation in therapeutic resources are factors that contribute to a fatal outcome.


REFERENCES

  1. Cabezas-Poblet M, Pérez-García R, Argíz-Muñiz A, Quintero-Méndez Y. Hemofilia adquirida en el postparto. Presentación de un caso. Revista Finlay. 2012;2:5. Disponible en: http://revfinlay.sld.cu/index.php/finlay/article/view/122

  2. García CJ, Majluf CA. Hemofilia adquirida. Gac Med Mex. 2020;156:67-77.

  3. Moreno-Santillán AA, Briones-Vega CG, Díaz de León-Ponce MA, Gómez Bravo-Topete E, Martínez-Adame LM, Rodríguez-Roldán M, et al. Morbilidad extrema (near-miss) en obstetricia. Revisión de la literatura. Rev Mex Anestesiol. 2020;43:53-56.

  4. Castillo-Cañadas AM, Serrano-Diana C, López-Del Cerro E, Gómez-García MT, González De Merlo G. Diagnóstico y tratamiento de hemofilia A adquirida durante el posparto. Ginecol Obstet Mex. 2014;82:688-696.

  5. Benardete-Harari DN, Sánchez-Cárdenas AG, Meraz-Ávila D, Nellen-Hummel H, Halabe-Cherem J. Hemofilia adquirida. Una causa rara de hemorragia obstétrica. Med Int Méx. 2015;31:174-180.

  6. Núñez MME, Sánchez NMR, Álvarez SP. Experiencia de cinco años en el uso del rFVIIa en pacientes con sangrado en el Centro Médico ABC. Una alternativa terapéutica. An Med ABC. 2011;56:11-15.




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Rev Mex Anest. 2022;45