medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2022, Number 06

<< Back Next >>

Ginecol Obstet Mex 2022; 90 (06)

Altered maternal adipokine profile in preeclampsia

Saucedo R, Valencia-Ortega J, González-Reynoso R, Ramos-Martínez EG, Peña-Cano MI, Cruz-Durán JG

Language: Spanish
References: 43
Page: 475-485
PDF size: 253.68 Kb.


ABSTRACT

Objectives: To evaluate maternal serum concentrations of adipokines: adiponectin, adipsin, leptin, lipocalin-2, monocyte chemoattractant protein-1, nerve growth factor, resistin and tumor necrosis factor-alpha and their relationship with pre-pregnancy body mass index and gestational weight gain in women with preeclampsia compared with healthy women, and to perform an analysis classifying preeclampsia as early and late.
Materials and Methods: Cross-sectional, comparative, retrolective, non-probabilistic convenience sampling study carried out in patients attended at the Hospital de Gineco-Obstetricia 3, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS). Preoperatively, a blood sample was taken to determine serum adipokine concentrations by multianalyte assays.
Results: A sample of 75 women with healthy pregnancy and 44 with preeclampsia (early n = 20, late n = 24) was studied. Only adipsin, leptin, and tumor necrosis factor- alpha concentrations were higher in preeclampsia than in healthy pregnancy [median (interquartile range): 3. 9 μg/mL (2.9-5.4) vs. 2.5 µg/mL (1.9-3.1), 10.6 ng/mL (6.0-19.1) compared to 7.1 ng/mL (3.8-12.4), 3.6 pg/mL (2.7-5.8) vs. 2.9 (2.3-3.5), respectively]. Adipokine concentrations did not correlate with pre-pregnancy body mass index and gestational weight gain. There were no significant differences in concentrations between preeclampsia subtypes.
Conclusion: In the third trimester of pregnancy, preeclampsia is associated with an altered serum adipokine profile, characterized by elevated concentrations of adipsin, leptin, and tumor necrosis factor-alpha, which is not related to prepregnancy body mass index, gestational weight gain, and preeclampsia subtype.


REFERENCES

  1. The American College of Obstetricians and Gynecologists.ACOG practice bulletin no. 202: Gestational hypertensionand preeclampsia. Obstet Gynecol 2019;133:e1-e25. doi:10.1097/AOG.0000000000003018

  2. Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PFA.WHO analysis of causes of maternal death: a systematicreview. Lancet 2006; 367: 1066-74. doi: 10.1016/S0140-6736(06)68397-9

  3. Duley L. The global impact of preeclampsia and eclampsia.Semin Perinatol 2009; 33: 130-37. doi: 10.1053/j.semperi.2009.02.010.

  4. Instituto Nacional de Salud Pública. Encuesta Nacionalde Salud y Nutrición (ENSANUT) 2018. https://ensanut.insp.mx/encuestas/ensanut2018/doctos/informes/ensanut_2018_presentacion_resultados.pdf.

  5. Poorolajal J, Jenabi E. The association between bodymass index and preeclampsia: a meta-analysis. J MaternFetal Neonatal Med 2016; 29: 3670-76. doi:10.3109/14767058.2016.1140738

  6. Shao Y, Qiu J, Huang H, Mao B, Dai W, He X, et al. Pre-pregnancyBMI, gestational weight gain and risk of preeclampsia:a birth cohort study in Lanzhou, China. BMC PregnancyChildbirth 2017; 17: 400. doi 10.1186/s12884-017-1567-2

  7. Campbell EE, Dworatzek PDN, Penava D, de Vrijer B, GillilandJ, Matthews JI, et al. Factors that influence excessivegestational weight gain: moving beyond assessment andcounselling. J Matern Fetal Neonatal Med 2016; 29: 3527-31. doi: 10.3109/14767058.2015.1137894

  8. Blüher M, Mantzoros CS. From leptin to other adipokines inhealth and disease: facts and expectations at the beginningof the 21st century. Metabolism 2015; 64: 131-45. doi:10.1016/j.metabol.2014.10.016

  9. Huda SS, Brodie LE, Sattar N. Obesity in pregnancy: prevalenceand metabolic consequences. Semin Fetal NeonatMed 2010; 15: 70-76. doi: 10.1016/j.siny.2009.09.006

  10. Huda SS, Jordan F, Bray J, Love G, Payne R, Sattar N, et al.Visceral adipose tissue activated macrophage content andinflammatory adipokine secretion is higher in preeclampsiathan in healthy pregnancies. Clin Sci 2017; 131: 1529-40.doi: 10.1042/CS20160832

  11. Valencia-Ortega J, Zárate A, Saucedo R, Hernández-ValenciaM, Cruz JB, Puello E. Placental Proinflammatory State andMaternal Endothelial Dysfunction in Preeclampsia. GynecolObstet Invest 2019; 84:12-19. doi: 10.1159/000491087

  12. Talavera JO, Rivas-Ruiz R, Bernal-Rosales LP. Investigaciónclínica V. Tamaño de muestra. Rev Med Inst Mex SeguroSoc 2011; 49 (5): 517-22. https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=38846

  13. Institute of Medicine. Weight gain during pregnancy:Reexamining the guidelines. Washington, DC: NationalAcademy Press,2009. https://pubmed.ncbi.nlm.nih.gov/20669500/

  14. Organización Mundial de la Salud 2021.Obesidad y sobrepeso.

  15. Merck. Human adipokine magnetic bead panel 1-Endocrinemultiplex assay. https://www.merckmillipore.com/MX/es/product/MILLIPLEX-MAP-Human-Adipokine-Magnetic-Bead-Panel-1-Endocrine-Multiplex-Assay,MM_NFHADK1MAG-61K>

  16. Merck. Human adipokine magnetic bead panel 2-Endocrinemultiplex assay. Dirección URL:

  17. Poveda NE, Garcés MF, Ruiz-Linares CE, Varón D, ValderramaS, Sanchez E, et al. Serum adipsin levels throughoutnormal pregnancy and preeclampsia. Sci Rep 2016; 6:20073. doi: 10.1038/srep20073

  18. Chrelias G, Makris G-M, Papanota A-M, Spathis A, SalamalekisG, Sergentanis TN, et al. Serum inhibin and leptin: Riskfactors for preeclampsia? Clin Chim Acta 2016; 463: 84-87.doi: 10.1016/j.cca.2016.10.013

  19. Lau SY, Guild SJ, Barrett CJ, Chen Q, McCowan L, Jordan V,et al. Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are altered in preeclampsia: a systematicreview and meta-analysis. Am J Reprod Immunol 2013; 70:412-27. doi: 10.1111/aji.12138

  20. Wolf M, Kettyle E, Sandler L, Ecker JL, Roberts J, ThadhaniR. Obesity and preeclampsia: the potential role of inflammation. Obstet Gynecol 2001; 98: 757-62. doi: 10.1016/s0029-7844(01)01551-4

  21. Hansson SR, Nääv Å, Erlandsson L. Oxidative stress inpreeclampsia and the role of free fetal hemoglobin. FrontPhysiol 2015; 5: 516. doi: 10.3389/fphys.2014.00516

  22. Choy LN, Rosen BS, Spiegelman BM. Adipsin and an endogenouspathway of complement from adipose cells. JBiol Chem 1992; 267: 12736-41. doi: doi.org/10.1016/S0021-9258(18)42338-1

  23. Sivakumar K, Bari MF, Adaikalakoteswari A, Guller S,Weickert MO, Randeva HS, et al. Elevated fetal adipsin/acylation-stimulating protein (ASP) in obese pregnancy:novel placental secretion via Hofbauer cells. J Clin EndocrinolMetab 2013; 98: 4113-22. doi: 10.1210/jc.2012-4293

  24. Roberts JM, Escudero C. The placenta in preeclampsia.Pregnancy Hypertens 2012; 2: 72-83. doi: 10.1016/j.preghy.2012.01.001

  25. Lokki AI, Heikkinen-Eloranta J, Jarva H, Saisto T, Lokki M-L,Laivouri H, et al. Complement activation and regulation inpreeclamptic placenta. Front Immunol 2014; 5: 312. doi:10.3389/fimmu.2014.00312

  26. Pérez-Pérez A, Toro A, Vilariño-García T, Maymó J, GuadixP, Dueñas JL, et al. Leptin action in normal and pathologicalpregnancies. J Cell Mol Med 2018; 22: 716-27. doi:10.1111/jcmm.13369

  27. Haugen F, Ranheim T, Harsem NK, Lips E, Staff AC, DrevonCA. Increased plasma levels of adipokines in preeclampsia:relationship to placenta and adipose tissue gene expression.Am J Physiol Endocrinol Metab 2006; 290: E326-333.doi: 10.1152/ajpendo.00020.2005

  28. Meller M, Qiu C, Kuske BT, Abetew DF, Muy-RiveraM, Williams MA. Adipocytokine expression in placentasfrom pre-eclamptic and chronic hypertensivepatients. Gynecol Endocrinol 2006; 22: 267-73. doi:10.1080/09513590600630421

  29. Park M-J, Lee D-H, Joo B-S, Lee Y-J, Joo J-K, An B-S, et al.Leptin, leptin receptors and hypoxia-induced factor-1α expressionin the placental bed of patients with and withoutpreeclampsia during pregnancy. Mol Med Rep 2018; 17:5292-99. doi: 10.3892/mmr.2018.8539. doi: 10.3892/mmr.2018.8539

  30. Garonna E, Botham KM, Birdsey GM, Randi AM, Gonzalez-Perez RR, Wheeler-Jones CPD. Vascular endothelial growthfactor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenicactions of leptin on human endothelial cells. PLoSOne 2011; 6: e18823. doi: 10.1371/journal.pone.0018823

  31. Dalamaga M, Srinivas SK, Elovitz MA, Chamberland J,Mantzoros CS. Serum adiponectin and leptin in relationto risk for preeclampsia: results from a large case-controlstudy. Metabolism 2011; 60: 1539-44. doi: 10.1016/j.metabol.2011.03.021

  32. Nien JK, Mazaki-Tovi S, Romero R, Erez O, KusanovicJP, Gotsch F, et al. Adiponectin in severe preeclampsia.J Perinat Med 2007; 35: 503-12. doi: 10.1515/JPM.2007.121

  33. Stepan H, Philipp A, Reiche M, Klostermann K, Schrey S,Reisenbuchler C, et al. Serum levels of the adipokine lipocalin-2 are increased in preeclampsia. J Endocrinol Invest2010; 33: 629-32. doi: 10.1007/BF03346661

  34. Artunc-Ulkumen B, Guvenc Y, Goker A, Gozukara C. Relationshipof neutrophil gelatinase-associated lipocalin(NGAL) and procalcitonin levels with the presence andseverity of the preeclampsia. J Matern Fetal Neonatal Med2015; 28: 1895-1900. doi: 10.3109/14767058.2014.972926

  35. Szarka A, Rigó J Jr, Lázár L, Beko G, Molvarec A. Circulatingcytokines, chemokines and adhesion moleculesin normal pregnancy and preeclampsia determined bymultiplex suspension array. BMC Immunol 2010; 11: 59.doi: 10.1186/1471-2172-11-59

  36. D'souza V, Kilari A, Pisal H, Patil V, Mehendale S, WaghG, et al. Maternal nerve growth factor levels duringpregnancy in women with preeclampsia: A longitudinalstudy. Int J Dev Neurosci 2015; 47: 340-46. doi: 10.1016/j.ijdevneu.2015.08.003

  37. Dangat K, Kilari A, Mehendale S, Lalwani S, Joshi S. Higherlevels of brain derived neurotrophic factor but similar nervegrowth factor in human milk in women with preeclampsia.Int J Dev Neurosci 2013; 31: 209-13. doi: 10.1016/j.ijdevneu.2012.12.007

  38. Song Y, Gao J, Qu Y, Wang S, Wang X, Liu J. Serum levels ofleptin, adiponectin and resistin in relation to clinical characteristicsin normal pregnancy and preeclampsia. Clin ChimActa 2016; 458: 133-37. doi: 10.1016/j.cca.2016.04.036

  39. Seol HJ, Oh MJ, Yeo MK, Kim A, Lee ES, Kim HJ. Comparisonof serum levels and the placental expression of resistinbetween patients with preeclampsia and normal pregnantwomen. Hypertens Pregnancy 2010; 29: 310-17. doi:10.3109/10641950902849850

  40. D'Anna R, Baviera G, Corrado F, Giordano D, De Vivo A,Nicocia G, et al. Adiponectin and insulin resistance in earlyandlate-onset preeclampsia. BJOG 2006; 113: 1264-69.doi: 10.1111/j.1471-0528.2006.01078.x

  41. Masuyama H, Segawa T, Sumida Y, Masumoto A, InoueS, Akahori Y, et al. Different profiles of circulating angiogenicfactors and adipocytokines between early- andlate-onset preeclampsia. BJOG 2010; 117: 314-20. doi:10.1111/j.1471-0528.2009.02453.x

  42. Salimi S, Farajian-Mashhadi F, Naghavi A, Mokhtari M, ShahrakipourM, Saravani M, et al. Different profile of serumleptin between early onset and late onset preeclampsia. DisMarkers 2014; 2014: 628476. doi: 10.1155/2014/628476

  43. Molvarec A, Szarka A, Walentin S, Beko W, Karádi I, ProhászkaZ, et al. Serum leptin levels in relation to circulatingcytokines, chemokines, adhesion molecules and angiogenicfactors in normal pregnancy and preeclampsia. Reprod BiolEndocrinol 2011; 9: 124. doi: 10.1186/1477-7827-9-124




2020     |     www.medigraphic.com