medigraphic.com
ISSN 1561-3046 (Electronic)

2021, Number 1

<< Back Next >>

Rev Cub Med Mil 2021; 50 (1)

Relationship of CagA/VacA genotypes of Helicobacter pylori with precursor lesions of gastric cancer

Martínez LL, Montero GTJ, Piñol JFN, Palomino BA, Miranda GO, Días MD

Language: Spanish
References: 11
Page:
PDF size: 279.06 Kb.


ABSTRACT

Introduction: Helicobacter pylori predisposes to gastric cancer. Individuals with CagA and VacA s1m1 strains develop more severe mucosal lesions. The Operative Link on Gastritis Assessment system allows determining the risk of cancer and defines atrophy as the typical lesion in the progression of chronic gastritis.
Objective: Relate the CagA and VacA genotypes of Helicobacter pylori with precursor lesions of gastric cancer.
Methods: A descriptive study was carried out in 62 patients. The variables included were the CagA and VacA genotypes of Helicobacter pylori and the OLGA stages (0, I, II, III, IV), which were related. The absolute frequency and the percentage were used as summary measures for qualitative variables. To evaluate the association between qualitative variables, the X2 test (chi-square) was applied. A level of statistical significance p≤0.05 was accepted. To explore the relationship between two dichotomous variables, the relative risk was used. We worked with a confidence level of 95 %.
Development: 68 % of the patients with atrophy had a CagA genotype and 55 % had a VacA s1m1 genotype. 6 % of the patients with CagA were in stage 0; 11 % in stage I; 40 % in stage II and 16 % in stage III. 37 % of the patients with VacA s1m1 were stage II.
Conclusions: The CagA and VacA s1m1 genotypes were the most frequent and were related to the presence of gastric atrophy.


REFERENCES

  1. Martínez Leyva L, Gutiérrez Cowan B, Rodríguez BL, Reyes Zamora O, Varona Linares Y, Páez Suárez D. Diagnóstico de la infección por Helicobacter pylori mediante serología, histología y cultivo. Rev Cub Med Mil. 2016 [acceso: 21/06/2018];45(3):344-53. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572016000300009&nrm=iso

  2. Zhou Y, Li H-Y, Zhang J-J, Chen X-Y, Ge Z-Z, Li X-B. Operative link on gastritis Assessment stage is an appropriate predictor of early gastric cancer. World J Gastroenterol. 2016 [acceso: 1/11/2019]; 22(13): 3670-8]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814653/

  3. Martínez Leyva L, Márquez Aleaga Y, Rodríguez González BL, Reyes Zamora O, Mora González SR. Presencia del gen cagA y de la citotoxina vacA del Helicobacter pylori en pacientes dispépticos. Rev Cub Med Mil. 2016 [acceso: 31/10/2019; 45(4):1-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572016000400009&nrm=iso

  4. Asociación Médica Mundial AMM. Declaración de Helsinki de la AMM - Principios éticos para las investigaciones médicas en seres humanos. 64ª Asamblea General: 2013 octubre. Fortaleza, Brasil: Asociación Médica Mundial (AMM); 2013 [acceso: 19/01/2020]. Disponible en: http://www.wma.net/es/30publications/10policies/b3/

  5. Koller J, Jensen M, Guerrer ML. Correlación Endoscópica-Histopatológica del Cag-A del Helicobacter pylori. Gac Med Bol. 2009 [acceso: 23/04/2020]; 32(1):13-15. Disponible en: https://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-29662009000100002&lng=es

  6. Morales Díaz M, Corrales Alonso S, Vanterpool Héctor M, Avalos Rodríguez R, Salabert Tortolo I, Hernández Díaz O. Cáncer gástrico: algunas consideraciones sobre factores de riesgo y Helicobacter pylori. Rev medica electronica. 2018 [acceso: 23/04/2020];40(2): [aprox. 11 p.]. Disponible en: http://www.revmedicaelectronica.sld.cu/index.php/rme/article/view/2513

  7. Galvão de Azevêdo Ioná, Carneiro Izabel Cristina Leal Muniz, Tomiya Marília Tokiko Oliveira, Burgos Maria Goretti Pessoa de Araújo. Gastric cancer and associated factors in hospitalized patients. Nutr. Hosp. 2015 [acceso: 23/04/2020]; 32(1): 283-90. Disponible en: http://dx.doi.org/10.3305/nh.2015.32.1.9071

  8. Zaidi SF. Helicobacter pylori associated Asian enigma: Does diet deserve distinction? World J Gastrointest Oncol. 2016 [acceso: 23/04/2020]; 8(4):341-50. DOI: 10.4251/wjgo.v8.i4.341

  9. Torres Jiménez F, Torres Bayona C. Fisiopatología molecular en la infección por Helicobacter pylori. 2016 [acceso: 23/04/2020]; 32 (3). Disponible en: http://rcientificas.uninorte.edu.co/index.php/salud/article/viewArticle/8383/-10413

  10. Uribe Echeverry PT, Acosta Cerquera MA, Arturo Arias BL, Jaramillo Arredondo Md, Betancur Pérez JF, Pérez Agudelo JM. Prevalencia genotípica de cagA y vacA en aislamientos de Helicobacter pylori de pacientes colombianos. Rev Cuba Med Tropical. 2019 [acceso: 23/04/2020];70 (3):[aprox. 10 p.] Disponible en: http://www.revmedtropical.sld.cu/index.php/medtropical/article/view/265

  11. Hierro González A, Garcia Vaca R, Lazo del Vallin S, Elvírez Gutiérrez A. Validación de prueba diagnóstica. Valor del ultrasonido hidrogástrico en la detección del cáncer gástrico. Revista Cubana de Investigaciones Biomédicas. 2018 [acceso: 23/04/2020];37(1):1-18. Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/94




2020     |     www.medigraphic.com