Arley VDA

Language: Spanish
References: 28
Page: 10-18
PDF size: 160.87 Kb.

ABSTRACT

Hyperparathyroidism after renal transplantation is a prevalent entity in this population, it generates a negative effect on the renal graft, presenting a greater risk of graft dysfunction, it also confers a risk of fracture, vascular calcification and mortality. Parathyroidectomy generates a documented decrease of 25% in baseline glomerular filtration rate in the different series reviewed. On graft survival, the evidence is contradictory, some studies indicate that it generates a decrease in graft survival, while in other series no change in transplant survival is documented. Pharmacological management with cinacalcet impresses as an adequate alternative in the management of hypercalcemia due to hyperparathyroidism without documented adenoma. Pharmacological management should be considered in patients with post-renal transplant hyperparathyroidism, for at least one year, and reserve parathyroidectomy only in those cases with documented adenoma or failure of treatment with cinacalcet.

REFERENCES

1. Eknoyan, G. et al. KDIGO 2012 Clinical PracticeGuideline for the Evaluation and Management ofChronic Kidney Disease. Kidney International Supplements(2013). Vol 3 | issue 1 | january (1) 2013.

2. Webster, A. et al. Chronic kidney disease. Lancet2017; 389: 1238–52. http://dx.doi.org/10.1016/S0140-6736(16)32064-5.

3. Romagnani, P. et al. Chronic Kidney Disease. NatureReviews | Disease Primers Volume 3 | ArticleNumber 17088 | 3. Doi:10.1038/Nrdp.2017.88.

4. Hill NR et al. (2016) Global Prevalence of ChronicKidney Disease – A Systematic Review and Meta-Analysis. PLoS one 11(7): e0158765. doi:10.1371/journal.pone.0158765.

5. Bouquegneau, A. et al. Bone Disease after KidneyTransplantation. Clin J Am Soc Nephrol. 2016. doi:10.2215/CJN.11371015.

6. Torregrosa, J. y Xoana Barros, X. Management ofhypercalcemia after renal transplantation. Nefrologia2013;33(6):751-7. doi:10.3265/Nefrologia.pre2013.Aug.11888

7. Torregrosa, J. et al. Recomendaciones de la SociedadEspañola de Nefrología para el manejo de las alteracionesdel metabolismo óseo-mineral en los pacientescon enfermedad renal crónica (S.E.N.-MM).Nefrologia 2011;31(Suppl.1):3-32. doi:10.3265/Nefrologia.pre2011.Jan.10816

8. Mawad, H. et al. Retrospective Study Looking atCinacalcet in the Management of Hyperparathyroidismafter Kidney Transplantation. Journal of Transplantation.Volume 2017, Article ID 8720283, 6 pages.https://doi.org/10.1155/2017/8720283

9. Zavvos, V. et al. Long-Term Use of Cinacalcet inKidney Transplant Recipients With HypercalcemicSecondary Hyperparathyroidism: A Single-CenterProspective Study. Experimental and ClinicalTransplantation (2018) 3: 287-293. DOI: 10.6002/ect.2016.0342.

10. Cohen, J. et al. Cinacalcet for the Treatment ofHyperparathyroidism in Kidney Transplant Recipients:A Systematic Review and Meta-analysis.Transplantation & Volume 94, Number 10, November27, 2012. DOI: 10.1097/TP.0b013e31826c3968.

11. Evenepoel, P. et al. A Randomized Study Evaluating Cinacalcet to Treat Hypercalcemia in RenalTransplant Recipients With Persistent Hyperparathyroidism. American Journal of Transplantation2014; 14: 2545–2555. doi: 10.1111/ajt.12911.

12. Palmer, S. et al. Interventions for preventing bonedisease in kidney transplant recipients (Review). CochraneDatabase of Systematic Reviews 2019, Issue10. Art. No.: CD005015. DOI: 10.1002/14651858.CD005015.pub4.

13. Nakai, K. et al. Effect of cinacalcet cessation onhyperparathyroidism in kidney transcaplant patientsafter long-term dialysis therapy. Clin Exp Nephrol.DOI 10.1007/s10157-015-1107-1.

14. Massimetti, C. et al. Long-term efficacy of cinacalcetin the treatment of persistent hypercalcemichyperparathyroidism in renal transplant patients.Nephrology Dialysis Transplantation, Volume 32,Issue suppl_3, 1 May 2017, Pages iii242-iii243. DOI:10.1093/ndt/gfx147.SP384.

15. Wazna, E. et al. Treatment of Persistent Hypercalcemiaand Hyperparathyroidism With CinacalcetAfter Successful Kidney Transplantation. TransplantationProceedings , 48, 1623e1625 (2016). http://dx.doi.org/10.1016/j.transproceed.2016.01.044.

16. Pinho, L. et al. Cinacalcet in the treatment of persistenthyperparathyroidism after kidney transplantation. Clinical Nephrology, Vol. 75 – No. 3/2011(263-268). DOI 10.5414/CNP75263

17. Ah, H. et al. Effect of Cinacalcet in Kidney TransplantPatients With Hyperparathyroidism. TransplantationProceedings , 51, 1397e1401 (2019). https://doi.org/10.1016/j.transproceed.2019.01.141.

18. Lou, I. et al. Parathyroidectomy is Underutilizedin Patients with Tertiary Hyperparathyroidismafter Renal Transplantation. Surge ry. 2016 January ;159(1): 172–180. doi:10.1016/j.surg.2015.08.039.

19. Patecki, M. et al. Long-term renal graft outcomeafter parathyroidectomy - a retrospective single centerstudy. BMC Nephrology (2020) 21:53. https://doi.org/10.1186/s12882-020-01723-x.

20. Van der Plas, W. et al. Timing of ParathyroidectomyDoes Not Influence Renal Function AfterKidney Transplantation. World J Surg. https://doi.org/10.1007/s00268-019-04952-w.

21. Pui, P. et al. Effects of Parathyroidectomy onRenal Allograft Survival . Kidney Blood Press Res2004;27:191–196. DOI: 10.1159/000079810

22. Evenepoel, P. et al. Impact of parathyroidectomyon renal graft function, blood pressure and serumlipids in kidney transplant recipients: a single centerstudy. Nephrol Dial Transplant (2005) 20: 1714–1720. doi:10.1093/ndt/gfh892

23. Schwarz, A. et al. Decreased renal transplantfunction after parathyroidectomy. Nephrol DialTransplant (2007) 22: 584–591. doi:10.1093/ndt/gfl583.

24. Dulfer, R. et al. Systematic review of surgical andmedical treatment for tertiary hyperparathyroidism.BJS 2017; 104: 804–813. DOI: 10.1002/bjs.10554.

25. Cruzado, J. et al. A Randomized Study ComparingParathyroidectomy with Cinacalcet for TreatingHypercalcemia in Kidney Allograft Recipients withHyperparathyroidism. J Am Soc Nephrol 27: 2487–2494, 2016. doi: 10.1681/ASN.2015060622.

26. Soliman, A. et al. Cinacalcet versus Parathyroidectomyin the Treatment of Secondary HyperparathyroidismPost Renal Transplantation. ROM. J. INTERN.MED., 2016, 54, 3, 184–189. DOI: 10.1515/rjim-2016-0027.

27. Dulfer, R. et al. Parathyroidectomy versus cinacalcetfor tertiary hyperparathyroidism; a retrospectiveanalysis . Langenbeck’s Archives of Surgery(2019) 404:71–79. https://doi.org/10.1007/s00423-019-01755-4.

28. Finnerty, B. et al. Parathyroidectomy versus Cinacalcetin the Management of Tertiary Hyperparathyroidism:Surgery Improves Renal Transplant AllograftSurvival. Surgery 0 0 0 (2018) 1–6. https://doi.org/10.1016/j.surg.2018.04.09