medigraphic.com
SPANISH

Revista Cubana de Pediatría

ISSN 1561-3119 (Electronic)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2021, Number 1

<< Back Next >>

Rev Cubana Pediatr 2021; 93 (1)

Clinical-epidemiological characterization of 77 children and adolescents infected with SARS-CoV-2 coronavirus

Cabrera SL, Zamora TA, Guerreiro NMC, Alvariño CD, Suárez GM, Bello AJ, Betancourt CE
Full text How to cite this article

Language: Spanish
References: 32
Page: 1-14
PDF size: 726.58 Kb.


Key words:

SARS-CoV-2, children, clinical manifestations, epidemiology.

ABSTRACT

Introduction: Children are also vulnerable to Sars-CoV-2 infections, but their clinical manifestations are slight and the evolution in most of the cases is satisfactory.
Objective: Characterize in a clinical-epidemiological way pediatric patients infected with the new SARS-CoV-2 coronavirus.
Methods: Descriptive, cross-sectional and retrospective study in the first 77 patients under 18 years confirmed with COVID-19 and admitted in the pediatric service of “Dr. Luis Díaz Soto” Hospital, in the period from March 13th to June 30th, 2020. From the clinical records were taken data of variables like age and sex, comorbidities, source of infection and place of exposure, presence of symptoms and time of onset after the contact, and period in which started an improvement of the disease.
Results: There was a discreet predominance of female sex (54.5 %) and the adolescents (51.8 %) being more vulnerable to the infection. Comorbidities were noticed in 23 cases (22.8 %) and asthma was the most frequent (10-13%). It was specified the source of infection in 74 patients (96.1 %) and 58 patients (75.3 %) were asymptomatic during the diagnosis. The most frequent symptoms were: respiratory ones (cough: 7-36.8 %; rhinorrhoea: 5-26.3 %; and sneezing: 4-21,0 %); followed by cephalalgia with 4 (21,0 %); just 3 patients presented fever (15.8 %) and other 3 presented anosmia-dysgeusia (15.8 %).The evolution was favorable in 100.0 % of the patients and most of them were asymptomatic at the seventh day.
Conclusions: The infection by SARS-CoV-2 was present with significative distinction of sex, more commonly in adolescents with slight manifestations of the disease and satisfactory evolution. There were no deaths.


REFERENCES

  1. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. China medical treatment expert group for covid-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020 [acceso 20/03/2020];382(18):1708-20. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMoa2002032

  2. Lu R, ZhaoX, LiJ, Niu P, Yang B, Wu H, Ni ZY, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implicationsfor virus origins and receptor binding. Lancet. 2020 [acceso 20/03/2020];395(10224):565-74. Disponible en:https://www.thelancet.com/article/S0140-6736(20)30251-8/fulltext

  3. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 [acceso 20/03/2020];382(8):727-33.Disponible en: http://search.ebscohost.com/login.aspx?direct=true&db=mdc&AN=31978945&lang=es&site=ehost-live

  4. World Health Organization. Novel coronavirus(China 2020.[acceso 22/03/2020] Disponibleen: http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en

  5. World Health Organization WHO Director-General's opening remarks at the media briefing on COVID-19. Geneva: WHO; 2020 [acceso 22/03/2020] Disponible en: https://www.who.int/dg/speeches/detail/who-directorgeneral-s-opening-remarks-at-the-media-briefingon-covid-19---11-march-2020

  6. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus inWuhan, China. Lancet. 2020 [acceso: 22/03/2020];395(497):e506. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

  7. Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, et al. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579(7798):265-9.doi:https://doi.org/10.1038/s41586-020-2008-3

  8. Liu YC, Kuo RL, Shih SR.COVID-19: The first documented coronavirus pandemic in history. Biomed J. 2020;43,(4):328-33. doi: https://doi.org/10.1016/j.bj.2020.04.007

  9. Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis.2020[ acceso 22/03/2020];20(6):633-4. Disponible en:https://www.sciencedirect.com/science/article/pii/S1473309920301985

  10. Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J. SARS-CoV-2 infection in children. New England J Med. 2020 [acceso 22/03/2020];382(17):1663-5. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMc2005073

  11. Wu Z, McGoogan JM. Characteristics of and importantlessonsfromthe coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72?314 cases from the Chinese Center for disease Control and Prevention. JAMA. 2020 [acceso22/03/2020];323(13):1239-42. Disponible en: https://jamanetwork.com/journals/jama/article-abstract/2762130

  12. Cai J, Xu J, Lin D, Xu L, Qu Z, Zhang Y, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020 [acceso 20/04/2020];12;71(6):1547-51. Disponible en: https://www.ipna-online.org/wp-content/uploads/2020/04/Acase-series-of-10-Chinese-children-with-COVID-19-infection-outside-of-WuhanChina_EN.pdf

  13. Ministerio de Salud Pública. Coronavirus en Cuba. Información oficial del Ministerio. Sitio oficial del gobierno. La Habana: Minsap; 2020 [acceso: 22/07/2020]. Disponible en: https://salud.msp.gob.cu/

  14. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395(10237):1607-8. doi: 10.1016/S0140-6736(20)31094-1. Epub 2020 May 7.

  15. Jones VG, Mills M, Suarez D, Hogan CA, Yeh D, Segal JB, , et al. COVID-19 and Kawasaki Disease: Novel Virus and Novel Case. Hosp Pediatr. 2020;10(6):537-40. doi: 10.1542/hpeds.2020-0123. Epub 2020 Apr 7.

  16. Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395(10239):1771-8. doi: 10.1016/S0140-6736(20)31103-X. Epub 2020 May 13.

  17. De Biasi RL, Song X, Delaney M, Bell M, Smith K, Pershad J, et al. Severe COVID-19 in children and young adults in the Washington, D. C.: Metropolitan Region. J Pediatr. 2020;( 20):30581-3.

  18. Ministerio de Salud Pública. Protocolo de actuación nacional para la COVID-19. Versión 1.4. Mayo 2020. La Habana: Minsap; 2020 [acceso 12/06/2020]. Disponible en: https:// temas.sld.cu/coronavirus/covid-19/

  19. Bialek S, GierkeR, Hughes M, Skoff T. Coronavirus Disease 2019 in Children. United States, February 12 April 2, 2020. MMWR. 2020 [acceso 22/03/2020];69(14):422-6. Disponibl en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147903/

  20. Livingston E, Bucher K. Coronavirus Disease 2019 (COVID-19) in Italy. JAMA. 2020 [acceso23/03/2020];323(14):1335. Disponible en: https://jamanetwork.com/journals/jama/article-abstract/2763401

  21. López GL, Noda Albelo AL, Castro Pacheco BL, Causa Palma ND, Cabrera Solís L, Hernández Hernández JM. Caracterización clínico epidemiológica de 183 niños cubanos con infección por SARS-CoV-2. Rev Cubana Pediatr. 2020 [acceso 23/10/2020];92(Supl. Especial) e:1256. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1256.

  22. Zheng F, Liao C, Fan Q-H, Chen HB, Zhao XG. Clinical Characteristics of children with coronavirus disease 2019 in Hubei, China. Current Med Sci. 2020 [acceso 23/03/2020];40(2):275-80. Disponible en: https://doi.org/10.1007/s11596-020-2172-6

  23. Acosta TJ, Pérez Cutiño M, Rodriguez Prieto M, Morales González A. COVID-19 en pediatría: aspectos clínicos, epidemiológicos, inmunopatogenia, diagnóstico y tratamiento. RevCubana Pediatr. 2020 [12/08/2020];92(Supl. Especial):e1152. Disponible en: https://www.revpediatría.sld.cu/index.php/ped/article/view

  24. Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020 May;55(5):1169-1174. doi: 10.1002/ppul.24718. Epub 2020 Mar 5.

  25. Dong Y, Mo X, Hu Y, Qi X, Jiang F. Jian Z, et al.Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. J Pediatr. 2020 [acceso 23/03/2020];58(4):712-3.Disponible en: https://www.aappublications.org/news

  26. Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L,et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA. 2020 [acceso 23/03/2020];323(14):1406-7. Disponible en: https://www.jamanetwork.com/journals/jama/article-abstract/2762028

  27. Bi Q, Wu Y, Mei S, Ye C, Zou X, Zhang Z, et al.Epidemiology and transmission of COVID-19 in Shenzhen China: Analysis of 391 cases and 1,286 of their close contacts. MedRxiv.2020. doi: https://doi.org/10.1101/2020.03.03.20028423

  28. Backer JA, Klinkenberg D, Wallinga J. Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020. Euro Surveill. 2020;25(5):2000062. doi: 10.2807/1560-7917.ES.2020.25.5.2000062

  29. Wang XF, Yuan J, Zheng YJ, Chen J, Bao YM, Wang YR, et al. Clinical and epidemiologicalcharacteristics of 34 childrenwith 2019 novel coronavirus infection in Shenzhen. Chinese J Pediatr. 2020[acceso23/03/2019];58:e008. Disponible en: https://europepmc.org/article/med/32062875

  30. Lara S, Shekerdemian LS, Mahmood NR, Wolfe KK et al. Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr. 2020;174(9):868-873. doi:10.1001/jamapediatrics.2020.1948 2020

  31. Hong H, Wang Y, Chung HT, Chen CJ. Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children. Pediatr Neonatol. 2020;61(131):e2. doi: 10.1016/j.pedneo.2020.03.001

  32. Tullie L, Ford K, Bisharat M, Watson T, Thakkar H, Mullassery D, et al. Gastrointestinal features in children with COVID-19: an observation of varied presentation in eight children. Lancet Child Adolesc Health. 2020;4(7):e19-e20. doi: 10.1016/S2352-4642(20)30165-6. Epub 2020 May 20.




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Cubana Pediatr. 2021;93