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ISSN 1995-9494 (Electronic)
Revista del Hospital Clínico Quirúrgico "Arnaldo Milián Castro"

2021, Number 2

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Acta Med Cent 2021; 15 (2)

Alteraciones morfométricas cardíacas en ratas con síndrome metabólico

Yanes MB, López PR, Triana PI, Pérez RN, Menéndez HEM, Milián RO

Language: Spanish
References: 30
Page: 204-214
PDF size: 443.65 Kb.


ABSTRACT

Introduction: metabolic syndrome is characterized by histological and functional alterations of the heart and the use of morphometric methods is an essential tool in the evaluation of cardiac cellular morphology.
Objective: to describe the histomorphometric differences in the cardiac muscle of a model of healthy rats and another group subjected to a state of metabolic syndrome.
Methods: a developmental, correlational, cross-sectional research study using a system of morphometric methods was conducted in the period from October 2015 to September 2019. Histological heart slices corresponding to 16 male Sprague-Dawley rats, randomly distributed in two experimental groups, were analyzed, with three images taken from each processed heart sample. Descriptive statistical techniques were used to characterize the sample by the different variables studied, and the one-factor ANOVA parametric test for analysis of variance was applied for group comparisons.
Results: there was variability in the morphometric parameters studied and the diseased group offered the highest values of cellular area and nuclear area. These findings are consistent with the natural evolution of left ventricular hypertrophy in the course of metabolic syndrome.
Conclusions: muscle fiber area and nuclear area were higher in the induced treated group.


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