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ISSN 1029-3043 (Electronic)

2021, Number 2

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Medicentro 2021; 25 (2)

Acute progressive disseminated histoplasmosis in an immunocompetent patient

Ghaddar FN, Vila TAA, Hernández NH

Language: Spanish
References: 8
Page: 345-354
PDF size: 369.01 Kb.


ABSTRACT

Progressive disseminated histoplasmosis is a unique and rare expression of the infection cause by Histoplasma capsulatum. Its acute forms of presentation usually appear in patients with severe immunodeficiency disorders (mainly HIV). However, even patients without proven immunodeficiency can develop this condition in regions of high endemicity. We present a 47-year-old male patient with a previous history of severe pulmonary histoplasmosis eighteen years earlier. The patient was admitted due to the presence of fever, asthenia, night sweats, dyspnea, dry cough, hepatosplenomegaly, anemia and marked thrombocytopenia. He progressed to acute respiratory failure and was admitted to the intensive care unit requiring invasive mechanical ventilation. Growth of Histoplasma capsulatum was demonstrated in the bronchoalveolar lavage sample and a non-caseating granulomatous reaction was found in the bone marrow, confirming the diagnosis of progressive disseminated histoplasmosis. The patient received amphotericin B treatment and made a full recovery within a few weeks.


REFERENCES

  1. George S, Deepe Jr. Histoplasma capsulatum. En: Bennet JE, Raphael D, Martin BJ, editors. Principles and practice of infectious diseases. 8th ed. Philadelfia: Elsevier Saunders; 2015. p. 2949-62.

  2. Kumar Bauddha N, Singh Jadon R, Mondal S, Vikram NK, Sood R. Progressive disseminated histoplasmosis in an immunocompetent adult: A case report. Intractable Rare Dis Res [internet]. 2018 [citado 13 dic. 2018];7(2):[aprox. 4 p.]. Disponible en: https://www.jstage.jst.go.jp/article/irdr/7/2/7_2018.01022/_pdf/-char/en

  3. Agarwal P, Capoor MR, Singh M, Gupta A, Chhakchhuak A, Debatta P. An Unusual Presentation of Disseminated Histoplasmosis: Case Report and Review of Pediatric Immunocompetent Patients from India. Mycopathologia [internet]. 2015 Jul. 1 [citado 13 dic. 2018];180:[aprox. 6 p.]. Disponible en: https://link.springer.com/article/10.1007/s11046-015-9917-y

  4. Azar MM, Hage CA. Clinical Perspectives in the Diagnosis and Management of Histoplasmosis. Clin Chest Med [internet]. 2017 Sep. [citado 13 dic. 2018];38(3):[aprox. 13 p.]. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0272523117300394?via%3Dihub

  5. Lawrence JW, Marwan M, Nathan C, Andrej S, Ryan FR, Chadi H. Histoplasmosis. Infect Dis Clin N Am. 2016;30:207-27.

  6. Fernández Andreu CM, Corral Varona C, Martínez Machín G, Rodríguez Barreras ME, Ruiz Pérez A. Histoplasmosis diseminada progresiva en pacientes con SIDA. Rev Cubana Med Trop [internet]. sep.-dic. 1996 [citado 13 dic. 2018];48(3):[aprox. 6 p.]. Disponible en: http://scielo.sld.cu/scielo.php?pid=S0375-07601996000300005&script=sci_arttext&tlng=en

  7. Monroy Vaca E, Martínez Machín G, Fernández Andreu CM, Illnait Zaragozí MT, García Rodríguez A, Perurena Lancha M, et al. Diagnóstico molecular de histoplasmosis diseminada en pacientes cubanos con sida. Rev Cubana Med Trop [internet]. 2014 [citado 13 dic. 2018];66(1):[aprox. 12 p.]. Disponible en: https://www.medigraphic.com/pdfs/revcubmedtro/cmt-2014/cmt141k.pdf

  8. Mahto SK, Gupta PK, Sareen S, Balakrishna AM, Suman SK. A rare case of progressive dissemin




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