2002, Number S1
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Arch Cardiol Mex 2002; 72 (S1)
Hypothyroidism protects the myocardium against reperfusion injury
Bobadilla I, Franco M, Cruz D, Zamora J, Robles SG, Chávez E
Language: Spanish
References: 7
Page: 27-30
PDF size: 62.66 Kb.
ABSTRACT
This work describes experimental results indicating that mitochondria from hypothyroid rats are resistant to suffer membrane permeability transition as induced by matrix calcium accumulation. It is also shown that hypothyroidism provides resistance to myocardial reperfusion injury, after a period of 5 min ischemia. It is concluded that the protection is due to a low expression of mitochondrial proteins, as well as to a lack in cardiolipin as constituent of the lipid bilayer of the inner mitochondrial membrane.
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Bobadilla I, Franco M, Cruz D, Zamora J, Robles SG, Chávez E: Hypothyroidism provides resistance to reperfusion injury following myocardium ischemia. Int J Biochem Cell Biol 2001; 33: 499-506.
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