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Medicina & Laboratorio

2021, Number 4

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Medicina & Laboratorio 2021; 25 (4)

Cold agglutinin disease: diagnosis, treatment and follow-up of a patient

Gálvez-Cárdenas KM, Morantes-Rubiano JF, Lotero-Cadavid AF

Language: Spanish
References: 23
Page: 735-750
PDF size: 105.31 Kb.


ABSTRACT

Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia characterized in the vast majority of cases by hemolysis mediated by IgM autoantibodies and complement C3d against erythrocyte membrane antigens, leading to extravascular hemolysis with propensity to thrombosis, affecting mainly females and older individuals. It is diagnosed by direct and fractionated Coombs test and a cold agglutinin titer ›1:64 at 4 °C. We describe the case of an 89-year-old woman with a constitutional syndrome and a 3-year history of anemia, who was diagnosed with cold agglutinin disease. Also, we include the diagnostic and treatment approach, and a brief review of the literature.


REFERENCES

  1. Hill QA, Stamps R, Massey E, Grainger JD,Provan D, Hill A. The diagnosis and managementof primary autoimmune haemolytic anaemia.Br J Haematol 2017;176:395-411. https://doi.org/10.1111/bjh.14478.

  2. Gelman R, Kharouf F, Ishay Y, Gural A. Coldagglutinin-mediated autoimmune hemolyticanemia in association with antiphospholipidsyndrome. Acta Haematol 2021:1-4. https://doi.org/10.1159/000516295.

  3. Barcellini W, Fattizzo B. The changing landscapeof autoimmune hemolytic anemia. Front Immunol2020;11:946. https://doi.org/10.3389/fimmu.2020.00946.

  4. Jäger U, Barcellini W, Broome CM, Gertz MA,Hill A, Hill QA, et al. Diagnosis and treatment ofautoimmune hemolytic anemia in adults: Recommendationsfrom the First International ConsensusMeeting. Blood Rev 2020;41:100648. https://doi.org/10.1016/j.blre.2019.100648.

  5. Kaur J, Mogulla S, Khan R, KrishnamoorthyG, Garg S. Transient cold agglutinins in a patientwith COVID-19. Cureus 2021;13:e12751.https://doi.org/10.7759/cureus.12751.

  6. Raghuwanshi B. Serological blood groupdiscrepancy and cold agglutinin autoimmunehemolytic anemia associated with novel coronavirus.Cureus 2020;12:e11495. https://doi.org/10.7759/cureus.11495.

  7. Berentsen S, Randen U, Tjønnfjord GE. Coldagglutinin-mediated autoimmune hemolytic anemia.Hematol Oncol Clin North Am 2015;29:455-471. https://doi.org/10.1016/j.hoc.2015.01.002.

  8. Gupta R, Singh S, Anusim N, Gupta S, Gupta S,Huben M, et al. Coronavirus disease 2019 andcold agglutinin syndrome: An interesting case.Eur J Case Rep Intern Med 2021;8:002387.https://doi.org/10.12890/2021_002387.

  9. Brugnara C, Berentsen S. UptoDate. Coldagglutinin disease. Países bajos: WoltersKluwer; 2021. Acceso 15 de junio de 2021.Disponible en https://www.uptodate.com/contents/cold-agglutinin-disease#H3360841552.

  10. Berentsen S, Malecka A, Randen U, TjønnfjordGE. Cold agglutinin disease: where dowe stand, and where are we going? Clin AdvHematol Oncol 2020;18:35-44.

  11. Berentsen S. How I manage patients with coldagglutinin disease. Br J Haematol 2018;181:320-330. https://doi.org/10.1111/bjh.15109.

  12. Broome CM. Diagnosis and treatment of coldagglutinin disease. Clin Adv Hematol Oncol2019;17:162-165.

  13. Atencia CJ, Quintero C. Primera serie de casosreportada en Colombia de la enfermedad poraglutininas frías primaria y secundaria. Iatreia2020;33:123-132. https://doi.org/10.17533/udea.iatreia.40.

  14. Berentsen S. How I treat cold agglutinin disease.Blood 2021;137:1295-1303. https://doi.org/10.1182/blood.2019003809.

  15. Baines AC, Brodsky RA. Complementopathies.Blood Rev 2017;31:213-223. https://doi.org/10.1016/j.blre.2017.02.003.

  16. Berentsen S, Ulvestad E, Langholm R, BeiskeK, Hjorth-Hansen H, Ghanima W, et al. Primarychronic cold agglutinin disease: a populationbased clinical study of 86 patients. Haematologica2006;91:460-466.

  17. Sharma K, Patel A. Livedo reticularis in coldagglutinin disease. N Engl J Med 2019;381:e27.https://doi.org/10.1056/NEJMicm1902289.

  18. Swiecicki PL, Hegerova LT, Gertz MA. Coldagglutinin disease. Blood 2013;122:1114-1121.https://doi.org/10.1182/blood-2013-02-474437.

  19. Berentsen S, Tjønnfjord GE. Diagnosis andtreatment of cold agglutinin mediated autoimmunehemolytic anemia. Blood Rev 2012;26:107-115. https://doi.org/10.1016/j.blre.2012.01.002.

  20. Silberstein LE, Berkman EM, SchreiberAD. Cold hemagglutinin disease associatedwith IgG cold-reactive antibody. AnnIntern Med 1987;106:238-242. https://doi.org/10.7326/0003-4819-106-2-238.

  21. Gertz MA. How I treat cold agglutinin hemolyticanemia. Clin Adv Hematol Oncol 2019;17:338–343.

  22. Berentsen S, Randen U, Vågan AM, Hjorth-HansenH, Vik A, Dalgaard J, et al. High response rateand durable remissions following fludarabine andrituximab combination therapy for chronic coldagglutinin disease. Blood 2010;116:3180-3184.https://doi.org/10.1182/blood-2010-06-288647.

  23. Courville KA. A 55-year-old man with coldagglutinin disease. J Emerg Nurs 2020;46:102-104. https://doi.org/10.1016/j.jen.2018.11.016.




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